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Titolo:
Elicitation of predictable immune responses by using live bacterial vectors
Autore:
Drabner, B; Guzman, CA;
Indirizzi:
GBF German Res Ctr Biotechnol, Div Microbiol, Vaccine Res Grp, D-38124 Braunschweig, Germany GBF German Res Ctr Biotechnol Braunschweig Germany D-38124 weig, Germany
Titolo Testata:
BIOMOLECULAR ENGINEERING
fascicolo: 3, volume: 17, anno: 2001,
pagine: 75 - 82
SICI:
1389-0344(200103)17:3<75:EOPIRB>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATTENUATED SALMONELLA-TYPHIMURIUM; RECOMBINANT LISTERIA-MONOCYTOGENES; BACILLUS-CALMETTE-GUERIN; SURFACE PROTEIN-A; TOXIN-B-SUBUNIT; YERSINIA-ENTEROCOLITICA O-9; DNA-MEDIATED IMMUNIZATION; VACCINE CARRIER STRAINS; SHIGELLA-FLEXNERI; PROTECTIVE IMMUNITY;
Keywords:
attenuated bacteria; carriers; DNA vaccines; mucosal immunity; vaccines;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
99
Recensione:
Indirizzi per estratti:
Indirizzo: Guzman, CA GBF German Res Ctr Biotechnol, Div Microbiol, Vaccine Res Grp, MascheroderWeg 1, D-38124 Braunschweig, Germany GBF German Res Ctr Biotechnol Mascheroder Weg 1 Braunschweig Germany D-38124
Citazione:
B. Drabner e C.A. Guzman, "Elicitation of predictable immune responses by using live bacterial vectors", BIOMOL ENG, 17(3), 2001, pp. 75-82

Abstract

There is an increasing need for novel vaccines able to stimulate efficientand long-lasting responses, which have also low production costs. To confer protective immunity following vaccination, the adequate type of response should be elicited. Vaccines based on attenuated bacterial carriers have contained production and delivery costs, and are able to stimulate more potent immune responses than non-replicating formulations. The improved knowledge on carrier physiology and host response, the availability of different mutants and highly sophisticated expression tools, and the possibility of co-administering modulators enable to trigger predictable responses according to the specific needs. Recent studies support the use of attenuated bacteria nut only as conventional carriers, but also as a delivery system for DNA vaccines against infectious agents and tumors. In this review we discuss the most widely used bacterial carrier systems for either antigens or nucleicacid vaccines, and the strategies which have been successfully exploited to modulate the immune responses elicited. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 00:12:23