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Titolo:
A Kampo formulation: Byakko-ka-ninjin-to (Bai-Hu-Jia-Ren-Sheng-Tang) inhibits IgE-mediated triphasic skin reaction in mice: The role of its constituents in expression of the efficacy
Autore:
Tatsumi, T; Yamada, T; Nagai, H; Terasawa, K; Tani, T; Nunome, S; Saiki, I;
Indirizzi:
Toyama Med & Pharmaceut Univ, Fac Med, Dept Pathogen Biochem, Inst Nat Med, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ Toyama Japan 9300194 Toyama 9300194, Japan Toyama Med & Pharmaceut Univ, Fac Med, Dept Pharmacognosy, Inst Nat Med, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ Toyama Japan 9300194 Toyama 9300194, Japan Toyama Med & Pharmaceut Univ, Fac Med, Dept Japanese Oriental Kampo Med, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ Toyama Japan 9300194 Toyama 9300194, Japan Gifu Pharmaceut Univ, Dept Pharmacol, Gifu 5028585, Japan Gifu Pharmaceut Univ Gifu Japan 5028585 t Pharmacol, Gifu 5028585, Japan Tsumura & Co, Tsumura Cent Labs, Kampo & Pharmacognosy Lab, Ami, Ibaraki 3001192, Japan Tsumura & Co Ami Ibaraki Japan 3001192 y Lab, Ami, Ibaraki 3001192, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 3, volume: 24, anno: 2001,
pagine: 284 - 290
SICI:
0918-6158(200103)24:3<284:AKFB(I>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PASSIVELY SENSITIZED MICE; CUTANEOUS REACTION; ANTIBODY;
Keywords:
vLPR; Byakko-ka-ninjin-to; allergic inflammation; triphasic cutaneous reaction; Glycyrrhizae Radix; Gypsum Fibrosum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Saiki, I Toyama Med & Pharmaceut Univ, Fac Med, Dept Pathogen Biochem, Inst Nat Med, Sugitani 2630, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ Sugitani 2630 Toyama Japan 9300194
Citazione:
T. Tatsumi et al., "A Kampo formulation: Byakko-ka-ninjin-to (Bai-Hu-Jia-Ren-Sheng-Tang) inhibits IgE-mediated triphasic skin reaction in mice: The role of its constituents in expression of the efficacy", BIOL PHAR B, 24(3), 2001, pp. 284-290

Abstract

We have demonstrated that oral administration of a Kampo formulation, Byakko-ka-ninjin-to (Bai-Hu-Jia-Ren-Sheng-Tang), inhibited IgE-mediated triphasic skin reaction, including immediate phase response (IPR), late phase response (LPR) and very late phase response (vLPR), in passively sensitized mice with anti-DNP IgE antibody: Variant formulations of Byakko-ka-ninjin-to without Gypsum Fibrosum (Sekko), Glycyrrhizae Radix (Kanzo) or Oryzae Semen (Kobei) attenuated the inhibitory effect as compared with that of Byakko-ka-ninjin-to. The decreased effect of Byakko-ka-ninjin-to without Kanzo was restored by the addition of Kanzo to the variant formulations before oral administration, while the decreased effect of Byakko-ka-ninjin-to without Sekko could not be recovered by the addition of Sekko, Comparison of HPLC profiles of variant formulations without one crude drug with that of original Byakko-ka-ninjin-to revealed that some peaks could be detected only when five constituent crude drugs were simultaneously present during the preparation of Byakko-ka-ninjin-to formulation. Since elimination of Sekko from the Byakko-ka-ninjin-to constituents attenuated the efficacy although it did notshow any activity per se, mutual interaction of Sekko with other constituents during the preparation may result in the production of new components, These findings suggest that the effect of Byakko-ka-ninjin-to formulation on cutaneous inflammatory disease can differ from the sum of the effect of the individual constituents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 10:38:25