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Titolo:
Hypotensive effects of captopril on physical properties of the arterial system in young and adult rats
Autore:
Chang, KC; Peng, YI; Tasi, YF; Tseng, YZ; Chen, HI;
Indirizzi:
Natl Taiwan Univ, Coll Med, Dept Physiol, Taipei 10018, Taiwan Natl TaiwanUniv Taipei Taiwan 10018 Dept Physiol, Taipei 10018, Taiwan Natl Taiwan Univ, Coll Med, Dept Internal Med, Taipei 10018, Taiwan Natl Taiwan Univ Taipei Taiwan 10018 Internal Med, Taipei 10018, Taiwan Tzu Chi COll Med & Human, Dept Physiol, Hualien, Taiwan Tzu Chi COll Med &Human Hualien Taiwan , Dept Physiol, Hualien, Taiwan
Titolo Testata:
BIOGERONTOLOGY
fascicolo: 1, volume: 2, anno: 2001,
pagine: 45 - 54
SICI:
1389-5729(2001)2:1<45:HEOCOP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-TUBE MODEL; SPONTANEOUSLY HYPERTENSIVE RATS; MECHANICAL-PROPERTIES; ANGIOTENSIN-II; NITRIC-OXIDE; AGE;
Keywords:
angiotension converting enzyme; aortic input impedance; captopril; exponentially tapered T-tube model; pulse wave reflection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Chang, KC Natl Taiwan Univ, Coll Med, Dept Physiol, Taipei 10018, Taiwan Natl Taiwan Univ Taipei Taiwan 10018 iol, Taipei 10018, Taiwan
Citazione:
K.C. Chang et al., "Hypotensive effects of captopril on physical properties of the arterial system in young and adult rats", BIOGERONTOL, 2(1), 2001, pp. 45-54

Abstract

We determined the acute effects of the angiotension converting enzyme inhibitor captopril on the arterial mechanics in rats at different ages, based on the exponentially tapered T-tube model. Male Wistar-Kyoto rats aged 4 and 12 months were individually referred to as young (n = 8) and adult rats (n = 8) and were anesthetized and thoractomized. The pulsatile aortic pressure and flow signals before and after the administration of captopril 120 mg/kg, i,p.) were measured by a high-fidelity pressure sensor and an electromagnetic flow probe, respectively. In each age group, captopril showed little change in basal heart I ate as well as cardiac output. However, captoprilproduced a drop of 15% in mean aortic pressure in young and a fall of 12% in adult rats. In addition, captopril reduced total peripheral resistance by 21% in young and by 23% in adult animals. As for the pulsatile nature of the arterial system, captopril had increased wave transit time of the lowerbody circulation of 10% in young and of 12% in adult rats. By contrast, captopril reduced wave reflection factor by 22% in young and by 25% in adult animals. in conclusion, the converting enzyme inhibitor captopril has a stiffness-decreasing effect on Windkessel vessels and a dilated effect on resistance arterioles in either young or adult rats. No age dependence of vascular response and reflex tachycardia to captopril has been found in rats between 4 and 12 months.

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Documento generato il 05/04/20 alle ore 06:58:02