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Titolo:
Heating stress patterns in Caenorhabditis elegans longevity and survivorship
Autore:
Michalski, AI; Johnson, ME; Cypser, JR; Yashin, AI;
Indirizzi:
Max Planck Inst Demog Res, D-18057 Rostock, Germany Max Planck Inst Demog Res Rostock Germany D-18057 18057 Rostock, Germany Inst Control Sci, Moscow 117806, Russia Inst Control Sci Moscow Russia 117806 Control Sci, Moscow 117806, Russia Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 nst Behav Genet, Boulder, CO 80309 USA
Titolo Testata:
BIOGERONTOLOGY
fascicolo: 1, volume: 2, anno: 2001,
pagine: 35 - 44
SICI:
1389-5729(2001)2:1<35:HSPICE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIFE-SPAN; DROSOPHILA-MELANOGASTER; OXIDATIVE DAMAGE; MORTALITY; RESISTANCE; GOMPERTZ; SURVIVAL; THERMOTOLERANCE; POPULATIONS; EXTENSION;
Keywords:
C. elegans; heat induced protection; heating stress; hormesis; longevity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Yashin, AI Max Planck Inst Demog Res, Doberaner Str 114, D-18057 Rostock, Germany Max Planck Inst Demog Res Doberaner Str 114 Rostock Germany D-18057
Citazione:
A.I. Michalski et al., "Heating stress patterns in Caenorhabditis elegans longevity and survivorship", BIOGERONTOL, 2(1), 2001, pp. 35-44

Abstract

Survival data from Chenorhabditis elegans strain TJ1060 (spe-9; fer-15) following brief exposure to 35 degreesC have been investigated. Three experiments with 3-day-old worms were conducted with heat duration ranging between0 and 12 hours. A statistically significant increase in life expectancy was observed in the groups heated for less than 2 hours, as compared to the unheated control groups. In different experiments P-values for the observed life spans under the hypothesis that heating has no influence on longevity were P < 0.004 after 0.5 hour heat, P < 0.012 after 1 hour heat and P < 0.055 after 2 hours of heating. A biphasic survival model with Gamma distributed frailty has been constructed to describe the survival of worms after heating. The increase in the remaining life expectancy is determined by more effective protection by heat-induced substances in the ages yanger than 27 days. The unheated control group demonstrated acquired heterogeneity of frailty with chronological age while the heat-induced substances defend the worms in a universal way and protect against the development of frailty.

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Documento generato il 04/04/20 alle ore 11:57:52