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Titolo:
Cell degeneration in the model system Podospora anserina
Autore:
Silar, P; Lalucque, H; Vierny, C;
Indirizzi:
Univ Paris 11, CNRS, UMR 8621, Inst Genet & Microbiol, F-91405 Orsay, France Univ Paris 11 Orsay France F-91405 et & Microbiol, F-91405 Orsay, France
Titolo Testata:
BIOGERONTOLOGY
fascicolo: 1, volume: 2, anno: 2001,
pagine: 1 - 17
SICI:
1389-5729(2001)2:1<1:CDITMS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOCHONDRIAL-DNA REARRANGEMENTS; ELONGATION-FACTOR EF-1-ALPHA; GROUP-II INTRONS; LIFE-SPAN; SACCHAROMYCES-CEREVISIAE; DROSOPHILA-MELANOGASTER; CYTOSOLIC TRANSLATION; NEUROSPORA-INTERMEDIA; SEXUAL REPRODUCTION; SENESCENT CULTURES;
Keywords:
cell degeneration; longevity; mitochondrial DNA; non conventional infectious element; Podospora anserina; respiration; translation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
104
Recensione:
Indirizzi per estratti:
Indirizzo: Silar, P Univ Paris 11, CNRS, UMR 8621, Inst Genet & Microbiol, Bat 400, F-91405 Orsay, France Univ Paris 11 Bat 400 Orsay France F-91405 F-91405 Orsay, France
Citazione:
P. Silar et al., "Cell degeneration in the model system Podospora anserina", BIOGERONTOL, 2(1), 2001, pp. 1-17

Abstract

Podospora anserina is a filamentous fungus used in many studies of fundamental cell biology, including cell ageing. In this organism, ageing is defined as a diminution of cell ability to proliferate and/or differentiate. This may or may not culminate with cell death. Two different ageing processes are intensively studied. The 'Senescence phenomenon is present in all wild-type strains, results in cell death and is caused by a yet undefined cytoplasmic and infectious element. It is associated with extensive mitochondrialDNA modifications. Longevity of the strains is controlled by a highly complex network of genes. Among these, those involved in cytosolic translation and respiratory metabolism an of special importance. The 'Crippled Growth' phenomenon is present only in strains with elevated translational accuracy. It does not result in cell death but in a severe impairment of cell growth, an acceleration of Senescence and a diminution of differentiation potencies. No mitochondrial DNA modification is associated with Crippled Growth. Another cytoplasmic and infectious element with peculiar properties, C, is causally involved in the set up of this cell degeneration. The study of P. anserina degenerative processes provides a conceptual framework to understand ageing in more complex organisms. Especially, it emphasises the complex control exerted by genes on longevity, the multiplicity of degenerative processes that may occur to cells with identical genotype and the potential role of non-conventional infectious elements in cell ageing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 13:44:09