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Titolo:
Desferrioxamine, an iron chelator, upregulates cyclooxygenase-2 expressionand prostaglandin production in a human macrophage cell line
Autore:
Tanji, K; Imaizumi, T; Matsumiya, T; Itaya, H; Fujimoto, K; Cui, CF; Toki, T; Ito, E; Yoshida, H; Wakabayashi, K; Satoh, K;
Indirizzi:
Hirosaki Univ, Sch Med, Inst Brain Sci, Dept Mol Biol, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan Hirosaki Univ, Sch Med, Inst Brain Sci, Dept Vasc Biol, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan Hirosaki Univ, Sch Med, Dept Dent & Oral Surg, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan Hirosaki Univ, Sch Med, Dept Pediat, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
fascicolo: 2-3, volume: 1530, anno: 2001,
pagine: 227 - 235
SICI:
1388-1981(20010226)1530:2-3<227:DAICUC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; TRANSCRIPTION FACTOR NF-IL6; ACTIVATED PROTEIN-KINASE; SMOOTH-MUSCLE CELLS; E-2 PRODUCTION; INTERFERON-GAMMA; RECEPTOR; U937; INTERLEUKIN-1-BETA; LIPOPOLYSACCHARIDE;
Keywords:
iron chelator; cyclooxygenase; prostaglandin; U937; macrophage; inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Tanji, K Hirosaki Univ, Sch Med, Inst Brain Sci, Dept Mol Biol, Zaifu Cho 5, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Zaifu Cho 5 Hirosaki Aomori Japan 0368562 62, Japan
Citazione:
K. Tanji et al., "Desferrioxamine, an iron chelator, upregulates cyclooxygenase-2 expressionand prostaglandin production in a human macrophage cell line", BBA-MOL C B, 1530(2-3), 2001, pp. 227-235

Abstract

Prostaglandins (PGs) play regulatory roles in a variety of physiological and pathological processes, including the immune response, cytoprotection and inflammation. Desferrioxamine (DFX), an iron chelator, is known to reducefree radical-mediated cell injury and to upregulate certain inflammatory mediators. We investigated the effects of DFX on the production of PGs and the expression of cyclooxygenase-2 (COX-2), the rate-limiting enzyme in the synthesis of PGs, using a human macrophage cell line, U937. Our results showed that COX-2 expression and PGE(2) production are upregulated by DFX treatment and that this upregulation is dependent on both COX-2 promoter activity and alteration of mRNA stability. COX-2 promoter activity may be, at least in part, mediated by activation of the extracellular signal-regulated kinase pathway. These findings suggest that iron metabolism may regulate inflammatory processes by modulating PGs as well as other inflammatory mediators. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:42:04