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Titolo:
Butyrate-induced differentiation of Caco-2 cells occurs independently fromp27
Autore:
Wachtershauser, A; Stein, J;
Indirizzi:
Univ Frankfurt, Dept Med 2, D-60590 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60590 d 2, D-60590 Frankfurt, Germany
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 281, anno: 2001,
pagine: 295 - 299
SICI:
0006-291X(20010223)281:2<295:BDOCCO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT KINASE INHIBITOR; CHAIN FATTY-ACIDS; INDUCED APOPTOSIS; COLONIC MUCOSA; BREAST CELLS; LOVASTATIN; P27(KIP1); CYCLE; EXPRESSION; CANCER;
Keywords:
butyrate; cell cycle; differentiation; HMG-CoA reductase; mevastatin; p27;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Wachtershauser, A Univ Frankfurt, Dept Med 2, Theodor Stern Kai 7, D-60590Frankfurt, Germany Univ Frankfurt Theodor Stern Kai 7 Frankfurt Germany D-60590
Citazione:
A. Wachtershauser e J. Stein, "Butyrate-induced differentiation of Caco-2 cells occurs independently fromp27", BIOC BIOP R, 281(2), 2001, pp. 295-299

Abstract

Butyrate, a short-chain fatty acid produced in the colon, reduces proliferation and increases differentiation of colon cancer cells. p27, an inhibitor of cyclindependent kinases and a negative regulator of the cell cycle, isthought to have a key function in the differentiation of various cell lines. The objective of the present study was to elucidate the role of p27 in butyrate-induced differentiation of the human colorectal carcinoma cell lineCaco-2, In this report we show that in spite of the increase in p27 protein expression after incubation with the HMG-CoA reductase inhibitor mevastatin, alkaline phosphatase activity decreases significantly in this cell line. In addition, mevastatin caused a significant increase in the cell cycle inhibitor p21. All effects could be reversed by addition of mevalonate to the medium. Taken together, we provide the first evidence that in Caco-2 cells p27 may have other functions apart from the regulation of cell differentiation. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:06:08