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Titolo:
Reversal effect of sulpiride on rotational behaviour of rats with unilateral frontal cortex ablation, an alternative explanation for the pharmacological mechanism of its antidepressant effect
Autore:
Kaneno, S; Fukamauchi, F; Komatsu, H; Koyama, K; Ikawa, K;
Indirizzi:
Tokyo Med & Dent Univ, Hlth Serv Ctr, Bunkyo Ku, Tokyo 1138510, Japan Tokyo Med & Dent Univ Tokyo Japan 1138510 unkyo Ku, Tokyo 1138510, Japan Tokyo Med & Dent Univ, Dept Neuropsychiat, Bunkyo Ku, Tokyo 1138510, JapanTokyo Med & Dent Univ Tokyo Japan 1138510 unkyo Ku, Tokyo 1138510, Japan
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 1, volume: 12, anno: 2001,
pagine: 69 - 73
SICI:
0955-8810(200102)12:1<69:REOSOR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; STRIATAL FUNCTION; DOPAMINE; DEPRESSION; ACID; HYPERACTIVITY; AMITRIPTYLINE; LESIONS;
Keywords:
sulpiride; dopamine; frontal cortex; methamphetamine; rotation; antidepressant; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Kaneno, S Tokyo Med & Dent Univ, Hlth Serv Ctr, Bunkyo Ku, 5-45 Yushima 1 Chome, Tokyo 1138510, Japan Tokyo Med & Dent Univ 5-45 Yushima 1 Chome Tokyo Japan 1138510
Citazione:
S. Kaneno et al., "Reversal effect of sulpiride on rotational behaviour of rats with unilateral frontal cortex ablation, an alternative explanation for the pharmacological mechanism of its antidepressant effect", BEHAV PHARM, 12(1), 2001, pp. 69-73

Abstract

The antidepressant effect of sulpiride has been generally explained as theresult of its preferential blocking effect on self-inhibitory presynaptic dopamine autoreceptors at low doses. Low dose haloperidol has the same blocking effect, In rats with unilateral ablation of the frontal cortex, methamphetamine administration induced mild contralateral rotation 10 days after the operation. We examined whether low dose sulpiride and haloperidol wouldhave the same effect on this rotational model. High dose sulpiride (100 mg/kg) or low dose haloperidol (0.05 mg/kg) prevented this methamphetamine-induced rotation, However, low dose (15 mg/kg) sulpiride clearly reversed thedirection of rotation, This reversal effect of low dose sulpiride is not explained by the preferential blocking effect on dopamine autoreceptors, Theresults suggest that low dose sulpiride, unlike low dose haloperidol, has a prominent blocking effect on D2 receptors in the frontal cortex, This unique effect of sulpiride may be relevant to its clinical antidepressant and anxiolytic effects at low doses. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 13:41:51