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Titolo:
Acute withdrawal from repeated cocaine treatment enhances latent inhibition of a conditioned fear response
Autore:
Murphy, CA; Heidbreder, C; Feldon, J;
Indirizzi:
ETH Zurich, Swiss Fed Inst Technol, Behav Biol Lab, CH-8603 Schwerzenbach,Switzerland ETH Zurich Schwerzenbach Switzerland CH-8603 3 Schwerzenbach,Switzerland
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 1, volume: 12, anno: 2001,
pagine: 13 - 23
SICI:
0955-8810(200102)12:1<13:AWFRCT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT NUCLEUS-ACCUMBENS; OBSESSIVE-COMPULSIVE DISORDER; BASAL EXTRACELLULAR DOPAMINE; RETENTION INTERVAL; DIFFERENTIAL INVOLVEMENT; BEHAVIORAL SENSITIZATION; FREEZING BEHAVIOR; AMPHETAMINE; SCHIZOPHRENIA; MODEL;
Keywords:
cocaine; sensitization; withdrawal; latent inhibition; aversive conditioning; schizophrenia; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Heidbreder, C ETH Zurich, Swiss Fed Inst Technol, Behav Biol Lab, Schorenstr 16, CH-8603Schwerzenbach, Switzerland ETH Zurich Schorenstr 16 Schwerzenbach Switzerland CH-8603
Citazione:
C.A. Murphy et al., "Acute withdrawal from repeated cocaine treatment enhances latent inhibition of a conditioned fear response", BEHAV PHARM, 12(1), 2001, pp. 13-23

Abstract

Psychostimulant-induced locomotor sensitization and disrupted latent inhibition (LI) of a classically conditioned association are two paradigms that have been widely studied as animal behavioural models of psychosis, In thisstudy we assessed the effects of withdrawal from the repeated intermittentadministration of cocaine on LI of a conditioned fear response. Animals which were either preexposed (PE) to a tone conditioned stimulus (CS) or naive to the tone (i.e. non-preexposed: NPE) subsequently experienced 10 pairings of the tone CS with footshock, Afterwards, both groups received five daily injections of cocaine (20 mg/kg, i.p.) or saline. After 3 days of withdrawal from drug treatment, animals were tested for conditioned freezing to the context of the footshock chamber, and 1 day later, for conditioned freezing to the tone CS, Cocaine-sensitized animals exhibited markedly enhanced LI compared to saline-treated animals, due to the fact that NPE-cocaine animals spent more time freezing during the tone CS than NPE-saline animals, whereas PE-cocaine animals showed a tendency toward reduced freezing compared to the saline groups. While these results suggest the presence of increased anxiety in cocaine-withdrawn NPE animals, the absence of this effect in cocaine-withdrawn PE rats indicates that cocaine withdrawal also influencesthe retrieval of previously learned information. (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 21/01/20 alle ore 07:06:50