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Titolo:
The D3R partial agonist, BP 897, attenuates the discriminative stimulus effects of cocaine and D-amphetamine and is not self-administered
Autore:
Beardsley, PM; Sokoloff, P; Balster, RL; Schwartz, JC;
Indirizzi:
Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA INSERM, U109, Ctr Paul Broca, Unite Neurobiol & Pharmacol Mol, F-75014 Paris, France INSERM Paris France F-75014 obiol & Pharmacol Mol, F-75014 Paris, France
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 1, volume: 12, anno: 2001,
pagine: 1 - 11
SICI:
0955-8810(200102)12:1<1:TDPAB8>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-3 DOPAMINE-RECEPTORS; RHESUS-MONKEYS; RATS; ABUSE; REINFORCEMENT; ANTAGONIST; ADDICTION; LIGANDS; DRUGS;
Keywords:
BP 897; cocaine; D-amphetamine; self-administration; drug-discrimination; mouse; rhesus monkey;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Beardsley, PM Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol, POB 980613,Richmond, VA 23298 USA Virginia Commonwealth Univ POB 980613 Richmond VA USA 23298
Citazione:
P.M. Beardsley et al., "The D3R partial agonist, BP 897, attenuates the discriminative stimulus effects of cocaine and D-amphetamine and is not self-administered", BEHAV PHARM, 12(1), 2001, pp. 1-11

Abstract

Growing attention has been directed towards the potential involvement of the dopamine D3 receptor (D3R) in modulating effects of psychomotor stimulants. BP 897 (N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-2-naphthylrarboxamide; aka BP 4.897 and DO897) is amongst the most selective partial agonists for the D3R receptor thus far reported. BP 897 was tested for its ability to support self-administration in rhesus monkeys (0.3-30 mug/kg) and for its ability to produce cocaine- and D-amphetamine-like discriminative stimulus effects in mice (0.01-17 mg/kg i.p.). BP 897 was not self-administered above vehicle and saline levels in any of the four monkeys tested, and produced less than 30% generalization from either the cocaine or D-amphetamine stimulus. When BP 897 was administered before administrations of cocaine orD-amphetamine, percent drug-lever selections were reduced, These results suggest that BP 897 has a profile of activity suitable for consideration as a potential treatment for cocaine dependency disorders. (C) 2001 LippincottWilliams & Wilkins.

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Documento generato il 22/01/20 alle ore 06:51:36