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Titolo:
A study of the genetic and environmental etiology of stuttering in a selected twin sample
Autore:
Felsenfeld, S; Kirk, KM; Zhu, G; Statham, DJ; Neale, MC; Martin, NG;
Indirizzi:
Duquesne Univ, Dept Speech Language Pathol, Pittsburgh, PA 15260 USA Duquesne Univ Pittsburgh PA USA 15260 ge Pathol, Pittsburgh, PA 15260 USA Univ Queensland, Queensland Inst Med Res, Brisbane, Qld, Australia Univ Queensland Brisbane Qld Australia Med Res, Brisbane, Qld, Australia Univ Queensland, Joint Genet Program, Brisbane, Qld, Australia Univ Queensland Brisbane Qld Australia Program, Brisbane, Qld, Australia Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA 23284 USA Virginia Commonwealth Univ Richmond VA USA 23284 , Richmond, VA 23284 USA
Titolo Testata:
BEHAVIOR GENETICS
fascicolo: 5, volume: 30, anno: 2000,
pagine: 359 - 366
SICI:
0001-8244(200009)30:5<359:ASOTGA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSYCHIATRIC-DIAGNOSIS; ASCERTAINMENT; BIAS;
Keywords:
Twins; stuttering; speech disorders; bivariate analysis; ascertainment bias;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Felsenfeld, S Duquesne Univ, Dept Speech Language Pathol, Pittsburgh, PA 15260 USA Duquesne Univ Pittsburgh PA USA 15260 tsburgh, PA 15260 USA
Citazione:
S. Felsenfeld et al., "A study of the genetic and environmental etiology of stuttering in a selected twin sample", BEHAV GENET, 30(5), 2000, pp. 359-366

Abstract

Stuttering is a developmental disorder of speech production that usually emerges in childhood. In this study, a large population-based twin sample from the Australian Twin Registry (1567 pairs and 634 singles aged 17-29 years) was screened to identify twin pairs in which one or both members reported themselves to be affected by stuttering. Telephone interview-based diagnoses were obtained for 457 of these individuals (self-reported affected cases, cotwins, and controls) to determine whether the self-report was correct. To correct for ascertainment bias we carried out a bivariate analysis of the final diagnosis in the selected sample with the screening item in the full sample, using the categorical raw data option of Mr 1.47c. After correcting for ascertainment bias, approximately 70% (95% confidence interval: 39-86%) of the variance in liability to stuttering was found to be attributable to additive genetic effects, with the remainder due to nonshared environmental effects.

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Documento generato il 28/09/20 alle ore 22:44:09