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Titolo:
Simvastatin improves arterial compliance in the lower limb but not in the aorta
Autore:
Shige, H; Dart, A; Nestel, P;
Indirizzi:
Baker Med Res Inst, Melbourne, Vic 8008, Australia Baker Med Res Inst Melbourne Vic Australia 8008 urne, Vic 8008, Australia
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 155, anno: 2001,
pagine: 245 - 250
SICI:
0021-9150(200103)155:1<245:SIACIT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; HYPERCHOLESTEROLEMIC PATIENTS; CARDIOVASCULAR MORTALITY; POSTMENOPAUSAL WOMEN; ELASTIC PROPERTIES; PULSE PRESSURE; STIFFNESS; CHOLESTEROL; DISEASE; DISTENSIBILITY;
Keywords:
arterial compliance; pulse wave velocity; LDL cholesterol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Nestel, P Baker Med Res Inst, POB 6492 St Kilda Rd, Melbourne, Vic 8008, Australia Baker Med Res Inst POB 6492 St Kilda Rd Melbourne Vic Australia 8008
Citazione:
H. Shige et al., "Simvastatin improves arterial compliance in the lower limb but not in the aorta", ATHEROSCLER, 155(1), 2001, pp. 245-250

Abstract

Several cardiovascular risk factors adversely affect arterial compliance or the distensibility of large arteries. The role of raised low-density lipoproteins (LDL) cholesterol is uncertain, most studies having shown little effect. We, therefore, investigated whether lowering LDL would improve arterial compliance. Twenty hypercholesterolemic subjects (LDL cholesterol 4.95 /- 1.11 mmol/l) were randomized to simvastatin (20 or 40 mg daily) or placebo, each for 4 weeks. Arterial function was assessed at the end of the placebo and simvastatin periods, systemic arterial compliance (SAC) and pulse wave velocities (PWV) centrally (aorto-femoral) and peripherally (femoral-posterior tibial). Results: Lipoproteins (LDL) cholesterol was reduced similarly with 20 and 40 mg simvastatin (ten subjects each dose) and data were pooled. Lipoproteins (LDL) cholesterol fell 39%, plasma triglyceride fell 18% and high-density lipoprotein (HDL) cholesterol rose 12%, all significant. Systemic arterial compliance (SAC) and central PWV did not change significantly but peripheral PWV showed evidence of greater compliance after simvastatin (10.1 +/- 1.3 vs. 9.4 +/- 1.3 m/s with placebo and simvastatin, P < 0.03), distensibility being inversely related to PWV. Improvement in PWV wasgreatest in those with poorest baseline values, r = 0.50; P < 0.02. Conclusion: Peripheral PWV was alone improved with LDL lowering probably because of the muscularity of that arterial bed; central PWV and SAC (in the elastic aorta) were not influenced. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:39:23