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Titolo:
Endothelial function of the popliteal artery in patients with coronary artery disease
Autore:
Angerer, P; Negut, C; Stork, S; von Schacky, C;
Indirizzi:
Klinikum Univ Munchen Innenstadt, Med Klin, D-80336 Munich, Germany Klinikum Univ Munchen Innenstadt Munich Germany D-80336 Munich, Germany
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 155, anno: 2001,
pagine: 187 - 193
SICI:
0021-9150(200103)155:1<187:EFOTPA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLD PRESSOR TEST; BRACHIAL-ARTERY; DEPENDENT DILATION; SYSTEMIC ARTERIES; ATHEROSCLEROSIS; DYSFUNCTION; FLOW; HUMANS; ACETYLCHOLINE; MECHANISM;
Keywords:
endothelial function; vasomotion; flow-mediated dilation; cold presser reaction; coronary artery disease; non-invasive; ultrasound;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Angerer, P Klinikum Univ Munchen Innenstadt, Med Klin, Ziemssenstr 1, D-80336 Munich,Germany Klinikum Univ Munchen Innenstadt Ziemssenstr 1 Munich Germany D-80336
Citazione:
P. Angerer et al., "Endothelial function of the popliteal artery in patients with coronary artery disease", ATHEROSCLER, 155(1), 2001, pp. 187-193

Abstract

Coronary artery disease (CAD) is associated more closely with atherosclerosis in the popliteal than in the brachial artery. This case-control study aimed at clarifying whether endothelial dysfunction of patients with CAD canbe detected non-invasively in the popliteal artery by means of ischemia-induced flow-mediated dilation (FMD) and cold presser reaction (CPR), and howit compares with the brachial artery. We further investigated a new mode of evaluation of the CPR. Eleven cases with CAD were compared with 16 matched healthy controls. Popliteal and brachial arterial diameter was monitored by ultrasound for 20 min following ischemia and cold presser. For CPR, the difference between maximum and minimum diameter was defined as maximum vasomotion. In the popliteal artery, maximum vasomotion and FMD were significantly smaller in cases than in controls, the difference being more pronouncedthan in the brachial artery, where only maximum vasomotion was significantly smaller. After exclusion of current smokers, only the difference in maximum vasomotion of both arteries remained significant. We conclude that maximum vasomotion may be more sensitive for detection of endothelial dysfunction than FMD. Endothelial dysfunction in patients with CAD is more pronounced in the popliteal artery than in the brachial artery. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 23:42:37