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Titolo:
Heme oxygenase-1 attenuates vascular remodeling following balloon injury in rat carotid arteries
Autore:
Tulis, DA; Durante, W; Peyton, KJ; Evans, AJ; Schafer, AI;
Indirizzi:
Baylor Coll Med, Dept Med, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Med, Dept Med, Houston, TX 77030 USA Baylor Coll Med, Dept Pharmacol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 ept Pharmacol, Houston, TX 77030 USA Vet Affairs Med Ctr, Houston, TX 77030 USA Vet Affairs Med Ctr Houston TXUSA 77030 s Med Ctr, Houston, TX 77030 USA
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 155, anno: 2001,
pagine: 113 - 122
SICI:
0021-9150(200103)155:1<113:HOAVRF>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; GROWTH-FACTOR GENE; NA+-H+ EXCHANGE; CARBON-MONOXIDE; INTIMAL HYPERPLASIA; CELLULAR PROLIFERATION; NEOINTIMAL FORMATION; ENDOTHELIAL-CELLS; CORONARY-ARTERY; VITAMIN-C;
Keywords:
heme oxygenase-1; arterial remodeling; neointima; restenosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Schafer, AI Baylor Coll Med, Dept Med, 6550 Fannin,SM MS 1423, Houston, TX77030 USA Baylor Coll Med 6550 Fannin,SM MS 1423 Houston TX USA 77030 SA
Citazione:
D.A. Tulis et al., "Heme oxygenase-1 attenuates vascular remodeling following balloon injury in rat carotid arteries", ATHEROSCLER, 155(1), 2001, pp. 113-122

Abstract

The heme oxygenase-l (HO-1) system of heme catabolism has been proposed toexert protective actions upon the cardiovascular system. This investigation examined the influence of HO-1 induction on vascular remodeling followingarterial injury. Rats were subjected to left carotid artery (LCA) balloon injury following pre-treatment with either vehicle, the HO-1 inducer hemin (50 mg/kg, SC), or concomitant treatment with hemin and the HO-1 inhibitor tin-protoporphyrin IX (SnPP-IX; 50 mu mol/kg, IP). Animals were injected daily for 14 days post-injury, after which animals were sacrificed and tissues obtained. Western blot analyses revealed vascular HO-1 induction after 2 and 16 days of hemin treatment. Positive immunostaining for HO-1 was detected in the endothelial and adventitial layers following 48 h of hemin treatment and positive medial staining for HO-1 after 16 days of hemin treatment. The injured LCA of hemin-treated animals demonstrated significantly attenuated neointimal (NI) area (- 57%), NI thickness (- 58%), and NI area/medialwall area ratio (- 40%) compared to the injured LCA of vehicle controls. The cross-sectional medial wall areas of both LCA and uninjured RCA were also significantly reduced in the hemin-treated animals. SnPP-IX treatment, however, completely restored the NI area, NI thickness, NI area/medial wall area ratio, and partially restored the medial wall area towards control levels. These results directly implicate HO-1 and the products of heme catabolism in attenuating the arterial response to injury and ensuing vascular wallremodeling. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:04:29