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Titolo:
Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation
Autore:
Ortmann, RA; Cheng, T; Visconti, R; Frucht, DM; OShea, JJ;
Indirizzi:
NIAMSD, Lymphocyte Cell Biol Sect, Arthrit & Rheumatism Branch, NIH, Bethesda, MD 20892 USA NIAMSD Bethesda MD USA 20892 eumatism Branch, NIH, Bethesda, MD 20892 USA Howard Hughes Med Inst, NIH Scholars Program, Bethesda, MD 20817 USA Howard Hughes Med Inst Bethesda MD USA 20817 gram, Bethesda, MD 20817 USA
Titolo Testata:
ARTHRITIS RESEARCH
fascicolo: 1, volume: 2, anno: 2000,
pagine: 16 - 32
SICI:
1465-9913(2000)2:1<16:JKASTA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE COMBINED IMMUNODEFICIENCY; PROTEIN-TYROSINE KINASE; CELL ANTIGEN-RECEPTOR; GROWTH-HORMONE RECEPTOR; INTERFERON-ALPHA/BETA RECEPTOR; STAT3 SERINE PHOSPHORYLATION; COLONY-STIMULATING FACTOR; PERIPHERAL T-CELLS; MICE LACKING JAK3; MOTH-EATEN MICE;
Keywords:
cytokines; signaling; Jak; Stat; immunoregulation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
238
Recensione:
Indirizzi per estratti:
Indirizzo: Ortmann, RA NIAMSD, Lymphocyte Cell Biol Sect, Arthrit & Rheumatism Branch, NIH, Bldg 10,Room 9N262, Bethesda, MD 20892 USA NIAMSD Bldg 10,Room 9N262Bethesda MD USA 20892 , MD 20892 USA
Citazione:
R.A. Ortmann et al., "Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation", ARTHRITIS R, 2(1), 2000, pp. 16-32

Abstract

Cytokines play a critical role in the normal development and function of the immune system. On the other hand, many rheumatologic diseases are characterized by poorly controlled responses to or dysregulated production of these mediators. Over the past decade tremendous strides have been made in clarifying how cytokines transmit signals via pathways using the Janus kinase (Jak) protein tyrosine kinases and the Signal transducer and activator of transcription (Stat) proteins. More recently, research has focused on several distinct proteins responsible for inhibiting these pathways. It is hoped that further elucidation of cytokine signaling through these pathways will not only allow for a better comprehension of the etiopathogenesis of rheumatologic illnesses, but may also direct future treatment options.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:10:27