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Titolo:
Detection and prediction of micrometastasis in the lymph nodes of patientswith pN0 gastric cancer
Autore:
Nakajo, A; Natsugoe, S; Ishigami, S; Matsumoto, M; Nakashima, S; Hokita, S; Baba, M; Takao, S; Aikou, T;
Indirizzi:
Kagoshima Univ, Sch Med, Dept Surg 1, Kagoshima 8910075, Japan Kagoshima Univ Kagoshima Japan 8910075 Surg 1, Kagoshima 8910075, Japan
Titolo Testata:
ANNALS OF SURGICAL ONCOLOGY
fascicolo: 2, volume: 8, anno: 2001,
pagine: 158 - 162
SICI:
1068-9265(200103)8:2<158:DAPOMI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
E-CADHERIN; PROGNOSTIC-SIGNIFICANCE; OCCULT MICROMETASTASES; MONOCLONAL-ANTIBODIES; ADHESION MOLECULES; COLORECTAL-CANCER; BREAST-CANCER; CARCINOMA; EXPRESSION; METASTASES;
Keywords:
micrometastasis; lymph node; cytokeratin; E-cadherin; prognosis; gastric cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Nakajo, A Kagoshima Univ, Sch Med, Dept Surg 1, 8-35-1 Sakuragaoka, Kagoshima 8910075, Japan Kagoshima Univ 8-35-1 Sakuragaoka Kagoshima Japan 8910075 Japan
Citazione:
A. Nakajo et al., "Detection and prediction of micrometastasis in the lymph nodes of patientswith pN0 gastric cancer", ANN SURG O, 8(2), 2001, pp. 158-162

Abstract

Background: The clinicopathologic significance of micrometastasis (MM) andtumor cell microinvolvement (TCM) in regional lymph nodes as identified byimmunohistochemical staining for cytokeratin expression was evaluated in patients with node-negative gastric cancer. Methods: MM was defined as tumor cells with stromal reaction, and TCM was defined as individual tumor cells without stromal reaction. We investigated1761 lymph nodes obtained from 67 gastric cancer patients whose diagnosis showed no lymph node metastasis by routine histological examination. The depth of tumor invasion was T1 (submucosa) in 33 patients and T2 (muscularis propria and subserosa) in 34 patients. The lymph nodes were examined immunohistochemically for the presence of tumor cells using anti-cytokeratin AE1/AE3 monoclonal antibody. Both the biopsy tumor specimens obtained prior to surgery and the resected primary tumors were immunostained with E-cadherin (E-cad) monoclonal antibody. Results: Thirty (1.5%) of the 1761 lymph nodes showed MM and/or TCM. MM with or without TCM was found in 10 patients, and TCM alone was found in 4 patients: 6 (18.2%) of the 33 patients with T1 tumor and 8 (23.5%) of the 34 patients with T2 turner had occult lymph node metastasis. The 5-year survival rate was worse among those with MM with or without TCM, than among thosewithout MM. Nearly all of the patients with MM and/or TCM had reduced or negative E-cad expression in the primary tumor. Conclusions: We demonstrated that the incidence of MM and/or TCM in the lymph nodes of patients with gastric cancer is quite high, and that such metastasis is associated with the prognosis of patients with pN0. Examination of E-cad expression in biopsy tumor specimens may be useful for predicting MM and/or TCM.

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Documento generato il 08/04/20 alle ore 10:30:06