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Titolo:
Exogenous surfactant changes the phenotype of alveolar macrophages in mice
Autore:
Kramer, BW; Jobe, AH; Ikegami, M;
Indirizzi:
Childrens Hosp, Med Ctr, Div Pulm Biol, Cincinnati, OH 45229 USA ChildrensHosp Cincinnati OH USA 45229 ulm Biol, Cincinnati, OH 45229 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 4, volume: 280, anno: 2001,
pagine: L689 - L694
SICI:
1040-0605(200104)280:4<L689:ESCTPO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCAVENGER RECEPTORS; POOL SIZES; IN-VIVO; PHOSPHATIDYLCHOLINE; RABBIT; DEGRADATION; LUNG; DIFFERENTIATION; REUTILIZATION; PROTEINOSIS;
Keywords:
surface markers; exogenous surfactant therapy; dipalmitoylphosphatidylcholine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Ikegami, M Childrens Hosp, Med Ctr, Div Pulm Biol, 3333 Burnet Ave, Cincinnati, OH 45229 USA Childrens Hosp 3333 Burnet Ave Cincinnati OH USA 45229 5229 USA
Citazione:
B.W. Kramer et al., "Exogenous surfactant changes the phenotype of alveolar macrophages in mice", AM J P-LUNG, 280(4), 2001, pp. L689-L694

Abstract

Alveolar macrophages are essential for the maintenance of surfactant homeostasis. We asked whether surfactant treatment would change alveolar macrophage number and whether the alveolar macrophage phenotype would become activated or apoptotic when challenged in vivo with exogenous surfactant. Surfactant pool size in mice was increased by repetitive surfactant treatments containing 120 mg/kg (110 mmol/kg) saturated phosphatidylcholine. The number of alveolar macrophages recovered by alveolar lavage decreased after the first dose by 49% and slightly increased after the second and third doses. Upto 28.5% of the macrophages became large and foamy, and their appearance normalized within 12 h. Surfactant treatment did not increase the percent ofapoptotic or necrotic cells. The alveolar macrophages were not activated as indicated by no change in expression of CD14, CD16, CD54, CD95, and scavenger receptor class A types I and II after surfactant treatment. Surfactanttreatment in healthy mice transiently changed the phenotype of alveolar macrophages to large and foamy without indications of changes in the surface markers characteristic of activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:42:49