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Titolo:
Nitric oxide production in the hypoxic lung
Autore:
Le Cras, TD; McMurtry, IF;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Pediat, Pediat Heart Lung Ctr, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 at Heart Lung Ctr, Denver, CO 80262 USA Univ Colorado, Hlth Sci Ctr, Cardiovasc Pulm Res Lab, Dept Med, Denver, CO80262 USA Univ Colorado Denver CO USA 80262 Res Lab, Dept Med, Denver, CO80262 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 4, volume: 280, anno: 2001,
pagine: L575 - L582
SICI:
1040-0605(200104)280:4<L575:NOPITH>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; RIGHT-VENTRICULAR HYPERTROPHY; PULMONARY ENDOTHELIAL-CELLS; HYPERTENSIVE RAT LUNGS; GENE-EXPRESSION; RELAXING FACTOR; OXYGEN-TENSION; OVINE FETUS; SYNTHASE; NO;
Keywords:
acute hypoxia; chronic hypoxia; pulmonary hypertension; nitric oxide synthase; isolated perfused lung;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Le Cras, TD Univ Colorado, Hlth Sci Ctr, Dept Pediat, Pediat Heart Lung Ctr, Box C218,4200 E 9th Ave, Denver, CO 80262 USA Univ Colorado Box C218,4200 E 9th Ave Denver CO USA 80262 USA
Citazione:
T.D. Le Cras e I.F. McMurtry, "Nitric oxide production in the hypoxic lung", AM J P-LUNG, 280(4), 2001, pp. L575-L582

Abstract

Nitric oxide (NO) is a potent vasodilator and inhibitor of vascular remodeling. Reduced NO production has been implicated in the pathophysiology of pulmonary hypertension, with endothelial NO synthase (NOS) knockout mice showing an increased risk for pulmonary hypertension. Because molecular oxygen(O-2) is an essential substrate for NO synthesis by the NOSs and biochemical studies using purified NOS isoforms have estimated the Michaelis-Menten constant values for O-2 to be in the physiological range, it has been suggested that O-2 substrate limitation may limit NO production in various pathophysiological conditions including hypoxia. This review summarizes numerousstudies of the effects of acute and chronic hypoxia on NO production in the lungs of humans and animals as well as in cultured vascular cells. In addition, the effects of hypoxia on NOS expression and posttranslational regulation of NOS activity by other proteins are also discussed. Most studies found that hypoxia limits NO synthesis even when NOS expression is increased.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:40:38