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Titolo:
Analysis of the immune status in the recipients with long-term well-functioning kidneys allografts
Autore:
Nakagawa, K; Matsuno, T; Iwagaki, H; Fujiwara, T; Tanaka, N;
Indirizzi:
Okayama Univ, Sch Med, Dept Surg 1, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 , Dept Surg 1, Okayama 7008558, Japan Tsuyama Chuo Hosp, Dept Surg, Tsuyama 7080841, Japan Tsuyama Chuo Hosp Tsuyama Japan 7080841 ept Surg, Tsuyama 7080841, Japan Kurashiki Med Ctr, Dept Surg, Kurashiki, Okayama 7100824, Japan Kurashiki Med Ctr Kurashiki Okayama Japan 7100824 Okayama 7100824, Japan
Titolo Testata:
ACTA MEDICA OKAYAMA
fascicolo: 1, volume: 55, anno: 2001,
pagine: 31 - 39
SICI:
0386-300X(200102)55:1<31:AOTISI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DONOR-SPECIFIC HYPORESPONSIVENESS; CELL-MEDIATED LYMPHOLYSIS; RENAL-TRANSPLANT RECIPIENTS; CLONAL ANERGY; LIMITING DILUTION; T-LYMPHOCYTES; TOLERANCE; UNRESPONSIVENESS; HYPOREACTIVITY; TRANSFUSIONS;
Keywords:
renal transplantation; long-term stable recipients; specific CTL unresponsiveness; interleukin-2; interleukin-2 receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Nakagawa, K Okayama Univ, Sch Med, Dept Surg 1, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 1, Okayama 7008558, Japan
Citazione:
K. Nakagawa et al., "Analysis of the immune status in the recipients with long-term well-functioning kidneys allografts", ACT MED OKA, 55(1), 2001, pp. 31-39

Abstract

The immune status of thirteen living and related kidney transplant recipients with stable allografts were examined. The immunological assays consisted of a mixed lymphocyte reaction (MLR), cell-mediated lympholysis (CML) assay, interleukin-2 (IL-2) production in mixed lymphocytes culture (MLC) and IL-2 receptor (IL-2 R) expression on MLC cells, The suppression rates of the monoclonal antibodies (mAbs) against IL-2 R were tested on MLRs, The stimulation indices (SI) of the MLR against both donor and third-party cells increased compared with those of pretransplantation. The MLC responder cells stimulated by donor cells produced detectable amounts of IL-2, these amounts were lower than those by third-party cells. The MLC cells against donor cells expressed IL-2 R alpha and beta chains to the same degree as those against third-party cells. Anti-IL-2 it mAbs equally inhibited the MLRs between recipient and donor or third-party cells. Cytotoxic T lymphocytes (CTL) against donor cells were not generated, even with the addition of recombinant IL-2 in any of recipients except one, while anti-donor CTL had been detected prior to transplantation and the CTL against third-party cells were induced in posttranspalnt CML assays, These results indicate that the clonal anergy phenomenon might mediate the specific CTL unresponsiveness observed in kidney transplant recipients and the anergy phenomenon might serve in thelong-term acceptance of allograft.

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Documento generato il 01/12/20 alle ore 22:14:34