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Titolo:
The efficacy of esmolol versus lidocaine to attenuate the hemodynamic response to intubation in isolated head trauma patients
Autore:
Levitt, MA; Dresden, GM;
Indirizzi:
Alameda Cty Med Ctr, Dept Emergency Med, Oakland, CA USA Alameda Cty Med Ctr Oakland CA USA , Dept Emergency Med, Oakland, CA USA
Titolo Testata:
ACADEMIC EMERGENCY MEDICINE
fascicolo: 1, volume: 8, anno: 2001,
pagine: 19 - 24
SICI:
1069-6563(200101)8:1<19:TEOEVL>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTROLLED CLINICAL-TRIAL; TRACHEAL INTUBATION; INTRAVENOUS LIDOCAINE; ENDOTRACHEAL INTUBATION; DOUBLE-BLIND; LARYNGOSCOPY; HYPERTENSION; PRESSURE; INDUCTION; FENTANYL;
Keywords:
esmolol; lidocaine; intubation; heart rate; blood pressure; hemodynamics; head trauma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Levitt, MA Highland Gen Hosp, Dept Emergency Med, 1411 E 31st St, Oakland,CA 94602 USA Highland Gen Hosp 1411 E 31st St Oakland CA USA 94602 94602 USA
Citazione:
M.A. Levitt e G.M. Dresden, "The efficacy of esmolol versus lidocaine to attenuate the hemodynamic response to intubation in isolated head trauma patients", ACAD EM MED, 8(1), 2001, pp. 19-24

Abstract

Objective: To assess the effect of esmolol vs lidocaine to attenuate the detrimental rise in heart rate and blood pressure during intubation of patients with isolated head trauma. Methods: This was a prospective, double-blind, randomized study, performed at an urban, county teaching emergency department. Participants were 30 patients with isolated head trauma. Each underwent a standardized intubation protocol including esmolol or lidocaine, bothat 2 mg/ kg. Results: Esmolol was used in 16 patients and lidocaine in 14. Mechanisms of injury included 12 assaults, 6 motor vehicle collisions, 6 falls, 4 auto-vs-pedestrian crashes, and 2 bicycle incidents. Mean ethanol level was 0.116 +/- 0.133 SD (range 0-0.482). Mean Glasgow Coma Scale (GCS) score was 7.9 +/- 4.0 SD. Cranial computed tomography (CT) hemorrhagic findings included 9 subdural/epidural hematomas, 6 cortex hemorrhages, and 2 multi-hemorrhages. Eleven patients received surgical intervention: 9 patientsreceived a craniotomy, and 2 a ventricular catheter. The 2-minute time interval around intubation was used to assess each drug's efficacy. The mean difference change between groups for heart rate was 4.0 beats/min (95% CI = -17.7 to 9.7 beats/min), for systolic blood pressure was 1.3 mm Hg (95% CI = -27.8 to 30.4 mm Hg), and for diastolic blood pressure was 2.6 mm Hg (95%CI = -27.1 to 21.9 mm Hg). The power of this study was 90% to detect a 20-beat/min difference in heart rate, a 35-mm Hg difference in systolic blood pressure, and a 20-mm Hg difference in diastolic blood pressure. Conclusions: Esmolol and lidocaine have similar efficacies to-attenuate moderate hemodynamic response to intubation of patients with isolated head trauma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:01:10