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Titolo:
Role of the peripheral intravenous catheter in false-positive D-dimer testing
Autore:
Heffner, AC; Kline, JA;
Indirizzi:
Carolinas Med Ctr, Dept Emergency Med, Charlotte, NC 28203 USA Carolinas Med Ctr Charlotte NC USA 28203 ncy Med, Charlotte, NC 28203 USA
Titolo Testata:
ACADEMIC EMERGENCY MEDICINE
fascicolo: 2, volume: 8, anno: 2001,
pagine: 103 - 106
SICI:
1069-6563(200102)8:2<103:ROTPIC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUSPECTED PULMONARY-EMBOLISM; AMBULATORY PATIENTS; PLASMA; DIAGNOSIS;
Keywords:
D-dimer; diagnosis; deep venous thrombosis; pulmonary embolism; thromboembolism; decision making; diagnostic tests; respiratory system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Kline, JA Emergency Med Clin Res, POB 32861, Charlotte, NC 28323 USA Emergency Med Clin Res POB 32861 Charlotte NC USA 28323 8323 USA
Citazione:
A.C. Heffner e J.A. Kline, "Role of the peripheral intravenous catheter in false-positive D-dimer testing", ACAD EM MED, 8(2), 2001, pp. 103-106

Abstract

Objective: To determine whether inserting a peripheral intravenous catheter (IV) can significantly increase the circulating D-dimer concentration. Methods: Twenty healthy young adult volunteers underwent cannulation of an antecubital vein with a 20-gauge Teflon IV. Time 0 venous blood was drawn during IV insertion. The IV was saline-locked and left in place for 90 minutes, at which time a second venipuncture was performed in a contralateral antecubital vein (+90 min). A qualitative D-dimer assay [erythrocyte-agglutination assay, SimpliRED (SRDD)] and a quantitative spectrophotometric assay [enzyme-linked immunosorbent assay (EIA), Dimertest Gold] were performed on all samples. Time 0 means (fSD) were compared with +90 min means by paired t-test, and SRDD pairs were compared with McNemar's test. Results: Time 0 initial venipuncture blood samples yielded a mean D-dimer concentration of 15+/- 24 ng/mL, with 2/20 SRDD tests read as positive (95% CI = 1% to 32%). At +90 min, the D-dimer concentration was 33 +/- 21 ng/mL (p = 0.04 vs time0), with 5/20 SRDD tests read as positive (95% CI = 9% to 49%, p = 0.248). Conclusions: Insertion of an IV increased the circulating D-dimer concentration (determined by EIA), but did not lead to a significant increase in false-positive conversion of the SRDD. An effort should be made to perform D-dimer testing on "first-stick" blood to optimize specificity. However, a strongly positive D-dimer reaction cannot be ascribed to the presence of an IV.

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Documento generato il 01/04/20 alle ore 11:30:33