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Titolo:
Central effects of sildenafil (Viagra) on auditory selective attention andverbal recognition memory in humans: a study with event-related brain potentials
Autore:
Schultheiss, D; Muller, SV; Nager, W; Stief, CG; Schlote, N; Jonas, U; Asvestis, C; Johannes, S; Munte, TF;
Indirizzi:
Univ Magdeburg, Dept Clin Neuropsychol, D-39112 Magdeburg, Germany Univ Magdeburg Magdeburg Germany D-39112 hol, D-39112 Magdeburg, Germany Hannover Med Sch, Dept Urol, D-3000 Hannover, Germany Hannover Med Sch Hannover Germany D-3000 Urol, D-3000 Hannover, Germany Hannover Med Sch, Dept Neurol, D-3000 Hannover, Germany Hannover Med Sch Hannover Germany D-3000 eurol, D-3000 Hannover, Germany
Titolo Testata:
WORLD JOURNAL OF UROLOGY
fascicolo: 1, volume: 19, anno: 2001,
pagine: 46 - 50
SICI:
0724-4983(200102)19:1<46:CEOS(O>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERECTILE DYSFUNCTION; ORAL SILDENAFIL; RETRIEVAL; STIMULI; WORDS; P300; AGE; ERP;
Keywords:
event-related potentials; recognition memory; auditory attention; central nervous system; sildenafil;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Munte, TF Univ Magdeburg, Dept Clin Neuropsychol, Lennestr 6, D-39112 Magdeburg, Germany Univ Magdeburg Lennestr 6 Magdeburg Germany D-39112 rg, Germany
Citazione:
D. Schultheiss et al., "Central effects of sildenafil (Viagra) on auditory selective attention andverbal recognition memory in humans: a study with event-related brain potentials", WORLD J URO, 19(1), 2001, pp. 46-50

Abstract

The purpose of this study was to assess possible central side-effects of sildenafil (Viagra) on attention and memory functions. Sildenafil and placebo were administered in young male subjects in a double-blind balanced cross-over design. Behavioral patterns and event-related brain potentials (ERP) were recorded in a spatial auditory attention and a visual word recognitiontask. While behavioral patterns did not reveal any overt effects of sildenafil, auditory ERPs were indicative of an enhanced ability to focus attention (amplitude enhancement of Nd-effect) and to select relevant target stimuli in the sildenafil condition (P3 component). In the memory task, CNS-effects of sildenafil were evident in a reduction of a negativity in the 150-250 ms range. No overt effects on behavior were observed. Nevertheless, the data reveal CNS-effects of sildenafil necessitating further studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:53:18