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Titolo:
Enhanced expression of the early retrotransposon in C3H mouse-derived myeloid leukemia cells
Autore:
Tanaka, I; Ishihara, H;
Indirizzi:
Natl Inst Radiol Sci, Bioregulat Res Grp, Inage Ku, Chiba 2638555, Japan Natl Inst Radiol Sci Chiba Japan 2638555 Inage Ku, Chiba 2638555, Japan
Titolo Testata:
VIROLOGY
fascicolo: 1, volume: 280, anno: 2001,
pagine: 107 - 114
SICI:
0042-6822(20010201)280:1<107:EEOTER>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG TERMINAL REPEAT; A-PARTICLE ELEMENT; NUCLEOTIDE-SEQUENCE; GENE FAMILY; STEM-CELLS; MICE; INSERTION; ETN; TRANSCRIPTION; RNA;
Keywords:
retrotransposon; gene expression; early transposon; VL30; intracisternal A particle; DNA-protein binding;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Ishihara, H Natl Inst Radiol Sci, Bioregulat Res Grp, Inage Ku, Anagawa 4-9-1, Chiba 2638555, Japan Natl Inst Radiol Sci Anagawa 4-9-1 Chiba Japan 2638555 Japan
Citazione:
I. Tanaka e H. Ishihara, "Enhanced expression of the early retrotransposon in C3H mouse-derived myeloid leukemia cells", VIROLOGY, 280(1), 2001, pp. 107-114

Abstract

Cells of acute myeloid leukemia (AML) from C3H/He mice express an increased amount of RNA for an endogenous retrovirus-like retrotransposon, intracisternal A-particle element. We analyzed the transcription of other mouse retrotransposons in C3H-derived tumor cells and found that all the AML lines from different mice overexpress early-transposon (ETn) RNA. In contrast, only faint levels of ETn were detected in the cells from other tumors, including hepatoma and lymphoma. The polyadenylation sites of the ETn RNA in the AMF cells varied. We also determined the binding site for the nuclear extract of the AML cells in the long terminal repeal: sequence of ETn. The overexpression of ETn as a common phenotype of AML cells suggests that myeloid cells with this phenotype are the origin of all the AML cells or that the phenotype is acquired during leukemogenesis. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 04:27:41