Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Brenner tumors but not transitional cell carcinomas of the ovary show urothelial differentiation: immunohistochemical staining of urothelial markers,including cytokeratins and uroplakins
Autore:
Riedel, I; Czernobilsky, B; Lifschitz-Mercer, B; Roth, LM; Wu, XR; Sun, TT; Moll, R;
Indirizzi:
Univ Hosp, Dept Pathol, D-35033 Marburg, Germany Univ Hosp Marburg Germany D-35033 Dept Pathol, D-35033 Marburg, Germany Tel Aviv Univ, Sackler Sch Med, Tel Aviv Sourasky Med Ctr, Inst Pathol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 Pathol, IL-69978 Tel Aviv, Israel Indiana Univ, Sch Med, Dept Pathol, Indianapolis, IN USA Indiana Univ Indianapolis IN USA Med, Dept Pathol, Indianapolis, IN USA NYU, Sch Med, Kaplan Comprehens Canc Ctr, Dept Dermatol, New York, NY USA NYU New York NY USA Comprehens Canc Ctr, Dept Dermatol, New York, NY USA NYU, Sch Med, Kaplan Comprehens Canc Ctr, Dept Pharmacol, New York, NY USANYU New York NY USA omprehens Canc Ctr, Dept Pharmacol, New York, NY USA NYU, Sch Med, Kaplan Comprehens Canc Ctr, Dept Urol, New York, NY USA NYUNew York NY USA lan Comprehens Canc Ctr, Dept Urol, New York, NY USA
Titolo Testata:
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
fascicolo: 2, volume: 438, anno: 2001,
pagine: 181 - 191
SICI:
0945-6317(200102)438:2<181:BTBNTC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
UTERINE CERVIX; MONOCLONAL-ANTIBODIES; EXPRESSION PATTERNS; MEMBRANE-PROTEINS; TISSUES; BLADDER; POLYPEPTIDES; ENDOMETRIAL; METAPLASIA; KERATIN-20;
Keywords:
Brenner tumor; transitional cell carcinoma of ovary; ovarian adenocarcinomas; cytokeratins; uroplakins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Moll, R Univ Hosp, Dept Pathol, D-35033 Marburg, Germany Univ Hosp Marburg Germany D-35033 thol, D-35033 Marburg, Germany
Citazione:
I. Riedel et al., "Brenner tumors but not transitional cell carcinomas of the ovary show urothelial differentiation: immunohistochemical staining of urothelial markers,including cytokeratins and uroplakins", VIRCHOWS AR, 438(2), 2001, pp. 181-191

Abstract

To determine whether Brenner tumors and transitional cell carcinomas (TCCs) of the ovary are urothelial in type, the immunoprofiles of 14 Brenner tumors, including three malignant examples, and eight ovarian TCCs were compared with those of Walthard nests, urothelium, 12 urinary bladder TCCs and 17ovarian adenocarcinomas (serous, endometrioid, mucinous, and undifferentiated type). The immunohistochemical stains used included those for cytokeratins CKs 5/6, CK7, CK8, CK13, and CK20, vimentin, CA125, and the specific urothelial differentiation marker uroplakin III. CK7 and CK8 were broadly expressed in most tumors of ovary and bladder examined, while vimentin was focally present in some ovarian TCCs and adenocarcinomas. As in normal and neoplastic bladder urothelium, urothelial markers, including uroplakin III, CK13, and CK20, were detected in the epithelial nests of bladder tumors. Brenner tumor cells also expressed uroplakins Ia and II. CA125 was observed focally in some Brenner tumors. In contrast, TCCs of the ovary and Walthard nests lacked uroplakins and were essentially negative for CK20 and CK13 but quite strongly expressed CA125. This immunophenotype closely resembled that found in ovarian adenocarcinomas. Thus, it appears that the only true urothelial-type ovarian neoplasm is the Brenner tumor, whereas ovarian TCC most likely represents a poorly differentiated adenocarcinoma with a morphologictransitional cell pattern. These results may explain the controversies as expressed in the recent literature concerning TCC of the ovary and establish its place among the ovarian adenocarcinomas of mullerian type.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 23:25:02