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Titolo:
Titin and ryanodine receptor autoantibodies in dogs with thymoma and late-onset myasthenia gravis
Autore:
Shelton, GD; Skeie, GO; Kass, PH; Aarli, JA;
Indirizzi:
Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 Pathol, La Jolla, CA 92093 USA Univ Bergen, Haukeland Hosp, Dept Neurol, N-5021 Bergen, Norway Univ Bergen Bergen Norway N-5021 osp, Dept Neurol, N-5021 Bergen, Norway Univ Calif Davis, Dept Populat Hlth & Reprod, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 at Hlth & Reprod, Davis, CA 95616 USA
Titolo Testata:
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
fascicolo: 1, volume: 78, anno: 2001,
pagine: 97 - 105
SICI:
0165-2427(20010110)78:1<97:TARRAI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE-RECEPTOR; 5 DOGS; ANTIBODIES; IGG; LOCALIZATION; PROTEINS; MODEL;
Keywords:
canine; muscle; myasthenia gravis; thymoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Shelton, GD Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA UnivCalif San Diego La Jolla CA USA 92093 olla, CA 92093 USA
Citazione:
G.D. Shelton et al., "Titin and ryanodine receptor autoantibodies in dogs with thymoma and late-onset myasthenia gravis", VET IMMUNOL, 78(1), 2001, pp. 97-105

Abstract

Similar to human autoimmune myasthenia gravis (MG), canine MG occurs spontaneously and is associated with autoantibodies against the nicotinic acetylcholine receptor (AChR). In addition to AChR, human MG patients with thymoma or late-onset MG have antibodies against titin and ryanodine receptor (RyR). The objective of this study was to establish if dogs with confirmed MG (AChR antibody titer >0.6 nmol/l) also developed titin and RyR antibodies and identify possible associations with thymoma, late age of onset, or severity of clinical signs. Sera from dogs (n = 430) with previously diagnosed autoimmune MG (N = 415), other immune-mediated neuromuscular disorders including polymyositis (PM) and masticatory muscle myositis (N = 5), and controldogs (N = 10) were evaluated for the presence of titin antibodies in ELISAusing MGT-30 as antigen, a peptide representing the main immunogenic region (MIR) for human titin antibodies. Titin antibody positive sera were further examined for RyR antibodies in Western blots using a RyR fusion protein (pc2-RyR) as antigen, which covers the MIR for human MG sera. Titin antibodies were found in sera of 80/430 dogs. Thymoma was present in 11/80 and ageof onset was after 4 years in 66/80 titin positive dogs. Two of the titin positive dogs had PM. RyR antibodies were found in 13/80 sera (8/13 thymoma, 12/13 age of onset after 4 years, and 1/13 PM). Neither titin nor RyR antibodies were found in sera of healthy control dogs. Acute fulminating MG was described in five dogs with both titin and RyR antibodies. From these studies we conclude that titin and RyR antibodies in canine and human MG have a similar association with thymoma, late-onset MG, and possibly with more severe forms of MG. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 05:50:08