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Titolo:
Analysis of the canine IgE-binding epitope on the major allergen (Cry j 1)of Japanese cedar pollen with anti-Cry j 1 monoclonal antibodies
Autore:
Sakaguchi, M; Masuda, K; Toda, M; Inouye, S; Yasueda, H; Taniguchi, Y; Nagoya, T; DeBoer, DJ; Tsujimoto, H;
Indirizzi:
Natl Inst Infect Dis, Dept Immunol, Tokyo, Japan Natl Inst Infect Dis Tokyo Japan Infect Dis, Dept Immunol, Tokyo, Japan Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Internal Med, Tokyo, Japan Univ Tokyo Tokyo Japan & Life Sci, Dept Vet Internal Med, Tokyo, Japan Natl Inst Infect Dis, Infect Dis Surveillance Ctr, Tokyo, Japan Natl Inst Infect Dis Tokyo Japan ect Dis Surveillance Ctr, Tokyo, Japan Natl Sagamihara Hosp, Clin Res Ctr Allergy & Rheumatol, Sagamihara, Kanagawa, Japan Natl Sagamihara Hosp Sagamihara Kanagawa Japan gamihara, Kanagawa, Japan Hayashibara Biochem Labs, Okayama, Japan Hayashibara Biochem Labs Okayama Japan ara Biochem Labs, Okayama, Japan Kowa Res Inst, Tsukuba, Ibaraki, Japan Kowa Res Inst Tsukuba Ibaraki Japan wa Res Inst, Tsukuba, Ibaraki, Japan Univ Wisconsin, Sch Vet Med, Dept Med Sci, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Dept Med Sci, Madison, WI 53706 USA
Titolo Testata:
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
fascicolo: 1, volume: 78, anno: 2001,
pagine: 35 - 43
SICI:
0165-2427(20010110)78:1<35:AOTCIE>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CRYPTOMERIA-JAPONICA POLLEN; MONKEYS MACACA-FUSCATA; J-I; POLLINOSIS; PREVALENCE; CLONING; HUMANS; SERA; DOGS;
Keywords:
Japanese cedar pollen; allergen; dog; epitope; IgE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Sakaguchi, M Natl Inst Infect Dis, Dept Immunol, Tokyo, Japan Natl Inst Infect Dis Tokyo Japan ept Immunol, Tokyo, Japan
Citazione:
M. Sakaguchi et al., "Analysis of the canine IgE-binding epitope on the major allergen (Cry j 1)of Japanese cedar pollen with anti-Cry j 1 monoclonal antibodies", VET IMMUNOL, 78(1), 2001, pp. 35-43

Abstract

In our previous study [Immunology 91 (1997) 161] using monoclonal antibodies (mAbs) specific to Cry j 1, a major allergen in Japanese cedar (Cryptomeria japonica) pollen, we identified five independent epitopes (EP-1-EP-5) on the molecule and found that EP-1 and EP-5 are the predominant allergic epitopes for humans and monkeys, respectively. In this study, we analyzed theepitopes recognized by IgE in the sera of 10 dogs sensitive to C. japonicapollen allergen using an IgE-ELISA inhibition method with these mAbs. The IgE reaction patterns varied among dogs. In eight of the 10 dogs, IgE recognized EP-5 which is a predominant allergic epitope for monkeys with the pollenosis. In four dogs, IgE recognized EP-1 which is a predominant allergic epitope for human patients with the pollenosis. In three dogs, IgE recognized EP-4 which is a heat-stable epitope. EP-5 is a predominant allergic epitope for dogs and some, but not all, dogs have IgE reaction patterns to the epitopes similar to those of humans. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 05/12/20 alle ore 14:02:04