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Titolo:
Clinical and histological evaluation of an analogue of palmitoylethanolamide, PLR 120 (comicronized Palmidrol INN) in cats with eosinophilic granuloma and eosinophilic plaque: a pilot study
Autore:
Scarampella, F; Abramo, F; Noli, C;
Indirizzi:
Studio Dermatol Vet, I-20133 Milan, Italy Studio Dermatol Vet Milan Italy I-20133 rmatol Vet, I-20133 Milan, Italy Univ Pisa, Dipartimento Patol Anim, Pisa, Italy Univ Pisa Pisa ItalyUniv Pisa, Dipartimento Patol Anim, Pisa, Italy
Titolo Testata:
VETERINARY DERMATOLOGY
fascicolo: 1, volume: 12, anno: 2001,
pagine: 29 - 39
SICI:
0959-4493(200102)12:1<29:CAHEOA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENING PRIMROSE OIL; MAST-CELL NUMBERS; MILIARY DERMATITIS; ATOPIC-DERMATITIS; GROWTH-FACTOR; FATTY-ACIDS; MANAGEMENT; GLUCOCORTICOIDS; RECEPTOR; DISEASE;
Keywords:
ALIAmides; cats; eosinophilic granuloma; eosinophilic plaque; mast cells; palmidrol; PLR-120; skin disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Noli, C Studio Dermatol Vet, Via Sismondi 62, I-20133 Milan, Italy Studio Dermatol Vet Via Sismondi 62 Milan Italy I-20133 an, Italy
Citazione:
F. Scarampella et al., "Clinical and histological evaluation of an analogue of palmitoylethanolamide, PLR 120 (comicronized Palmidrol INN) in cats with eosinophilic granuloma and eosinophilic plaque: a pilot study", VET DERMATO, 12(1), 2001, pp. 29-39

Abstract

Fifteen cats with eosinophilic granuloma or eosinophilic plaque were givenPLR 120 at the dosage of 10 mg kg(-1) twice daily for one month. PLR-120 down-modulates mast cell degranulation via a receptor-mediated mechanism. Noother drugs were permitted and cats were kept free of parasites throughoutthe study. A clinical evaluation and skin biopsies were performed before and after the treatment. Clinical improvement was assessed at 15 and 30 days. Mast cell numbers were counted and their granular content was assessed bydensitometric analysis on toluidine blue-stained sections before and afterthe treatment. Ten of 15 (67%) cats showed clinical improvement of signs and lesions. There was no significant difference between mast cell numbers in skin biopsies taken before and after the trial, whereas the number of granules was significantly increased (P < 0.009). This pilot study suggests that PLR-120 might be a useful drug for the treatment of eosinophilic granuloma and eosinophilic plaque.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:20:09