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Titolo:
Sulphido-leukotriene production from peripheral leukocytes and skin in clinically normal dogs and house dust mite positive atopic dogs
Autore:
Marsella, R; Nicklin, CF;
Indirizzi:
Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Blanche Saunders Dermatol Lab, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610atol Lab, Gainesville, FL 32610 USA
Titolo Testata:
VETERINARY DERMATOLOGY
fascicolo: 1, volume: 12, anno: 2001,
pagine: 3 - 12
SICI:
0959-4493(200102)12:1<3:SPFPLA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LPS-BINDING PROTEIN; TOTAL SERUM IGE; MAST-CELLS; DERMATOPHAGOIDES-FARINAE; ARACHIDONIC-ACID; SULPHIDOLEUKOTRIENE PRODUCTION; HISTAMINE-RELEASE; LATE-PHASE; DERMATITIS; CANINE;
Keywords:
canine atopy; leukotrienes; peripheral mononuclear cells; skin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Marsella, R Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Blanche Saunders Dermatol Lab, POB 100126, Gainesville, FL 32610 USA Univ Florida POB 100126 Gainesville FL USA 32610 FL 32610 USA
Citazione:
R. Marsella e C.F. Nicklin, "Sulphido-leukotriene production from peripheral leukocytes and skin in clinically normal dogs and house dust mite positive atopic dogs", VET DERMATO, 12(1), 2001, pp. 3-12

Abstract

Pathogenesis of canine atopy has not been completely elucidated. In humans, sulphido-leukotrienes (s-LT) play a role in atopy. and increased production of s-LT occurs in the skin and peripheral leukocytes after allergen challenge. The study population included 16 clinically normal and 13 atopic dogs. All atopic dogs had in common a positive reaction (4+) to the intradermal injection of house dust mite (allergen of reference). Blood samples and skin biopsies were collected. Sulphido-LT synthesis by peripheral leukocytesafter stimulation was measured, and no statistically significant difference was found between clinically normal and atopic dogs. Sulphido-LT concentrations in skin samples from stimulated and unstimulated sites were measured, and no statistically significant difference was detected between clinically normal and atopic dogs or between lesional and nonlesional skin within the atopic group. Clinical signs of atopic dogs were graded by owners and nocorrelation was found between their severity and cutaneous concentrations of s-LT. In this study there was no increase in s-LT synthesis in atopic dogs.

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Documento generato il 05/04/20 alle ore 03:38:28