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Titolo:
Discontinuation of alpha-blockade after initial treatment with finasterideand doxazosin for bladder outlet obstruction
Autore:
Baldwin, KC; Ginsberg, PC; Harkaway, RC;
Indirizzi:
Albert Einstein Med Ctr, Philadelphia, PA 19141 USA Albert Einstein Med Ctr Philadelphia PA USA 19141 ladelphia, PA 19141 USA
Titolo Testata:
UROLOGIA INTERNATIONALIS
fascicolo: 2, volume: 66, anno: 2001,
pagine: 84 - 88
SICI:
0042-1138(2001)66:2<84:DOAAIT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENIGN PROSTATIC HYPERPLASIA; EFFICACY;
Keywords:
alpha-blockade, discontinuation; finasteride; doxazosin; bladder outlet obstruction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Harkaway, RC 132 Country Club Dr, Moorestown, NJ 08057 USA 132 Country Club Dr Moorestown NJ USA 08057 wn, NJ 08057 USA
Citazione:
K.C. Baldwin et al., "Discontinuation of alpha-blockade after initial treatment with finasterideand doxazosin for bladder outlet obstruction", UROL INTERN, 66(2), 2001, pp. 84-88

Abstract

Objectives: Patients with symptomatic bladder outlet obstruction and moderately enlarged prostates can receive durable relief from finasteride. However, the delayed onset of action has led many clinicians to prescribe an alpha -blocker in addition to finasteride early in therapy for more rapid symptom relief. Our goal was to determine when to discontinue the alpha -blocker in this group of patients. Methods: We enrolled 100 consecutive men with an estimated prostate size of >40 g and an AUA symptom score of greater than or equal to 20, who reported an initially favorable response to combination therapy with 5 mg finasteride and 2 mg doxazosin daily. The average symptom score reduction at 1 month was 3.3. We discontinued the doxazosin at 3,6, 9, or 12 months, while continuing finasteride, then reevaluated patients 1 month later to determine if the patients reported any worsening of symptoms. Results: Twenty-five patients discontinued doxazosin at 3 months. Five (20%) were successfully discontinued, reporting no change in symptom score. Twenty reported worsening symptoms. Twenty-five patients discontinued doxazosin at 6 months. Twelve (48%) were success-fully discontinued, reporting no change in symptom scores. Thirteen (52%) reported worsening symptoms. Twenty-five patients discontinued doxazosin at 9 months. Twenty-one (84%) were successfully discontinued, reporting no change in symptom scores. Four (16%) reported worsening symptoms. Twenty-five patients discontinued doxazosin at 12 months. Twenty-one (84%) were successfully discontinued, reporting no change in symptom scores. Four (16%) reported worsening symptoms. Conclusion: Patients with symptomatic bladder outlet obstruction and moderatelyenlarged prostates who are placed initially on combination therapy using finasteride and an alpha -blocker are likely to tolerate discontinuation of the alpha -blocker after 9 months of combination therapy. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:10:21