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Titolo:
The effect of polychlorinated biphenyls on the high affinity uptake of theneurotransmitters, dopamine, serotonin, glutamate and GABA, into rat brainsynaptosomes
Autore:
Mariussen, E; Fonnum, F;
Indirizzi:
Norwegian Def Res Estab, Div Protect & Mat, N-2027 Kjeller, Norway Norwegian Def Res Estab Kjeller Norway N-2027 at, N-2027 Kjeller, Norway
Titolo Testata:
TOXICOLOGY
fascicolo: 1-2, volume: 159, anno: 2001,
pagine: 11 - 21
SICI:
0300-483X(20010221)159:1-2<11:TEOPBO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
REGIONAL ALTERATIONS; NEUROTOXICITY; CONGENERS; EXPOSURE; INHIBITION; METABOLISM; DISEASE; BIOACCUMULATION; AROCLOR-1254; TRANSPORT;
Keywords:
polychlorinated biphenyls (PCBs); neurochemical effects; synaptosomes; dopamine; glutamate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Mariussen, E Norwegian Def Res Estab, Div Protect & Mat, POB 25, N-2027 Kjeller, Norway Norwegian Def Res Estab POB 25 Kjeller Norway N-2027 Norway
Citazione:
E. Mariussen e F. Fonnum, "The effect of polychlorinated biphenyls on the high affinity uptake of theneurotransmitters, dopamine, serotonin, glutamate and GABA, into rat brainsynaptosomes", TOXICOLOGY, 159(1-2), 2001, pp. 11-21

Abstract

Studies have shown that polychlorinated biphenyls (PCB) may affect cognitive functions both in human and also in experimental animals. We have investigated whether this effect could be caused by an inhibition of the uptake of selected neurotransmitters into rat brain synaptosomes. Ortho-chlorinatedbiphenyls were found to inhibit transmitter transport into synaptosomes from rat brain. In contrast, several nonortho-chlorinated biphenyls did not inhibit uptake. The uptake of dopamine, glutamate, GABA and serotonin was inhibited by the PCB mixtures, Aroclor 1242 and 1254. Under identical condition, the uptake of dopamine was inhibited more efficient than that of glutamate. The inhibition of neurotransmitter uptake was found to be dependent onthe chlorination patterns of the PCB congeners, (i) ortho-chlorinated PCBswith four to five chlorine substituents (with the exception of 2,2',6,6'-TeCB) were the most effective inhibitors; (ii) hexa- or heptachlorinated PCBs were poor inhibitors or partial inhibitors (e.g. 2,2',4,4',5,5' HCB) of glutamate and GABA uptake. Kinetic studies indicated that Aroclor 1242 inhibited dopamine uptake mainly competitively. The uptake of glutamate and GABAwas inhibited in either a mixed competitive or in a non-competitive way, respectively. The neurotoxic concequences of the effect of different PCBs onneurotransmitter uptake on the uptake into synaptosomes are discussed. (C)2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:29:43