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Titolo:
The effect of zinc-crystallized glucagon-like peptide-1 on insulin secretion of macroencapsulated pancreatic islets
Autore:
Gappa, H; Baudys, M; Koh, JJ; Kim, SW; Bae, YH;
Indirizzi:
Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Ctr Controlled Chem Delivery, Salt Lake City, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 ivery, Salt Lake City, UT 84112 USA
Titolo Testata:
TISSUE ENGINEERING
fascicolo: 1, volume: 7, anno: 2001,
pagine: 35 - 44
SICI:
1076-3279(200102)7:1<35:TEOZGP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE-DEPENDENCY; GENE-EXPRESSION; RAT ISLETS; SHORT-TERM; IN-VITRO; TRANSPLANTATION; LANGERHANS; CELLS; HORMONE; RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Bae, YH Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Ctr Controlled Chem Delivery, Biomed Polymer Res Bldg,Room 205, Salt Lake City, UT 84112 USA Univ Utah Biomed Polymer Res Bldg,Room 205 Salt Lake City UT USA 84112
Citazione:
H. Gappa et al., "The effect of zinc-crystallized glucagon-like peptide-1 on insulin secretion of macroencapsulated pancreatic islets", TISSUE ENG, 7(1), 2001, pp. 35-44

Abstract

This research investigates the use of an insulinotropic factor, glucagon-like peptide-1 (GLP-1), to enhance insulin secretion from islets within a macrocapsule. A zinc-crystallized form of GLP-1 was added to the macrocapsuledevice to have a longer and more controlled release of the bioactive monomer GLP-1. The type of macrocapsule device used for this study consisted of a hollow fiber (MWCO 100,000 and 1 mm inner diameter) containing rat isletsand GLP-1 crystals within a poly(N-isopropylacrylamide-co-acrylic acid) (2mol% acrylic acid) matrix. When incubating the system in media with a highglucose concentration (300 mg/dL), insulin secretion was enhanced with a >85% increase after an induction period. When the same type of system was used in a dynamic perfusion experiment, similar results were obtained. GLP-1 crystals can be an effective form to be entrapped in a bioartificial pancreas to enhance insulin secretion function, especially at high glucose concentrations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:40:48