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Titolo:
Prolonged mild hypothermia therapy protects the brain against permanent focal ischemia
Autore:
Yanamoto, H; Nagata, I; Niitsu, Y; Zhang, Z; Xue, JH; Sakai, N; Kikuchi, H;
Indirizzi:
Natl Cardiovasc Ctr, Res Inst, Lab Cerebrovasc Disorders, Suita, Osaka 5658565, Japan Natl Cardiovasc Ctr Suita Osaka Japan 5658565 Suita, Osaka 5658565, Japan Hosp Natl Cardiovasc Ctr, Dept Cerebrovasc Surg, Osaka, Japan Hosp Natl Cardiovasc Ctr Osaka Japan ept Cerebrovasc Surg, Osaka, Japan
Titolo Testata:
STROKE
fascicolo: 1, volume: 32, anno: 2001,
pagine: 232 - 239
SICI:
0039-2499(200101)32:1<232:PMHTPT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIDDLE CEREBRAL-ARTERY; TISSUE-PLASMINOGEN ACTIVATOR; CAROTID TERRITORY STROKE; POSTISCHEMIC HYPOTHERMIA; NEURONAL INJURY; MODERATE HYPOTHERMIA; INFARCT SIZE; RATS; OCCLUSION; MODEL;
Keywords:
animal models; cerebral blood flow; cerebral infarction; cerebral ischemia; hypothermia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Yanamoto, H Natl Cardiovasc Ctr, Res Inst, Lab Cerebrovasc Disorders, 5-7-1 Fujishiro Dai, Suita, Osaka 5658565, Japan Natl Cardiovasc Ctr 5-7-1 Fujishiro Dai Suita Osaka Japan 5658565
Citazione:
H. Yanamoto et al., "Prolonged mild hypothermia therapy protects the brain against permanent focal ischemia", STROKE, 32(1), 2001, pp. 232-239

Abstract

Background and Purpose-The efficacy of hypothermic intervention for permanent focal ischemia has yet to be clarified. This study investigated the effect of a prolonged moderate or mild hypothermia on permanent focal ischemiain rats. Methods-Two permanent focal ischemia models in male Sprague-Dawley rats were used. Moderate (30 degreesC, in experiment 1) or mid (33 degreesC, in experiment 2) hypothermia was achieved at the time of the induction of focal ischemia and was maintained for 2 hours under general anesthesia. Thereafter, the hypothermic condition was maintained by means of a cold room for a total of 24 hours. The infarct volume and neurological function were analyzed for a maximum of 21 days and compared with that of the normothermia group. Regional cerebral blood flow was monitored for 6 hours in the ischemic core and penumbra region. Results-In experiment 1, the total infarct volume in the normothermic group was 368+/-59 mm(3); In contrast, it was significantly smaller in the hypothermia group: 169+/-33 mm(3) at 48 hours (mean+/-SEM, P<0.05). In experiment 2, the infarct volume was 211+/-19 mm(3) in the normothermia group and 88+/-15 mm(3) in the hypothermia group at 21 days (P<0.05). There were significant differences in neurological function from days 2 through 21 between the two groups. Mean regional cerebral blood flow in the penumbra region increased to a level >50% of baseline. Conclusions-Prolonged mild hypothermia suppressed the development of cerebral infarct and neurological deficit chronically after the induction of permanent focal ischemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:55:35