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Titolo:
Cell binding and internalisation of oligonucleotides
Autore:
Le Doan, T;
Indirizzi:
Univ Paris 11, CNRS UMR 8619, F-91405 Orsay, France Univ Paris 11 Orsay France F-91405 CNRS UMR 8619, F-91405 Orsay, France
Titolo Testata:
STP PHARMA SCIENCES
fascicolo: 1, volume: 11, anno: 2001,
pagine: 75 - 82
SICI:
1157-1489(200101/02)11:1<75:CBAIOO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYB ANTISENSE OLIGODEOXYNUCLEOTIDES; RECEPTOR-MEDIATED ENDOCYTOSIS; SMOOTH-MUSCLE CELLS; PHOSPHOROTHIOATE OLIGONUCLEOTIDES; HL-60 CELLS; IN-VIVO; PHOSPHODIESTER OLIGODEOXYNUCLEOTIDES; REVERSIBLE PERMEABILIZATION; INHIBITORY ACTIVITY; NUCLEAR DELIVERY;
Keywords:
oligonucleotides; cell binding; internalisation; cellular traffic; antisense;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Le Doan, T Univ Paris 11, CNRS UMR 8619, Batiment 430, F-91405 Orsay, France Univ Paris 11 Batiment 430 Orsay France F-91405 Orsay, France
Citazione:
T. Le Doan, "Cell binding and internalisation of oligonucleotides", STP PHARM S, 11(1), 2001, pp. 75-82

Abstract

In spite of their size and negative charges, oligonucleotides penetrate and distribute in cells. Internalisation of oligonucleotides by cells either as such or combined with transfection reagents proceeds via different routes including receptor-mediated endocytosis, pinocytosis and other pathways that have recently been described (oligonucleotide channel, potocytosis). Cell uptake and subcellular distribution depend on the type of cell, the structure of the oligomer and several other parameters that will be discussed. The way oligonucleotides route inside the cell will determine their chance of surviving lysosomal degradation, their meeting target macromolecules andthe incidence of their side effects or cytotoxicity. This review aims to describe some of the most recent advances in the study of cellular interactions of oligonucleotides. The collected data could be useful for those who intend to use antisense molecules as tools for fundamental cell biology studies (specific knockdown of protein) or as potential therapeutic agents in the treatment of various diseases (oligonucleotide-based therapeutics).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 19:21:49