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Titolo:
Targeting tumor vasculature with homing peptides from phage display
Autore:
Ruoslahti, E;
Indirizzi:
Burnham Inst, Ctr Canc Res, La Jolla, CA 92037 USA Burnham Inst La Jolla CA USA 92037 , Ctr Canc Res, La Jolla, CA 92037 USA
Titolo Testata:
SEMINARS IN CANCER BIOLOGY
fascicolo: 6, volume: 10, anno: 2000,
pagine: 435 - 442
SICI:
1044-579X(200012)10:6<435:TTVWHP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; ANGIOGENESIS IN-VIVO; ALPHA-V INTEGRINS; NG2 PROTEOGLYCAN; GENE-TRANSFER; MICE LACKING; RECEPTOR; CELLS; ALPHA-V-BETA-3; EXPRESSION;
Keywords:
homing; metastasis; angiogenesis; peptides; endothelial cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Ruoslahti, E Burnham Inst, Ctr Canc Res, La Jolla, CA 92037 USA Burnham Inst La Jolla CA USA 92037 s, La Jolla, CA 92037 USA
Citazione:
E. Ruoslahti, "Targeting tumor vasculature with homing peptides from phage display", SEM CANC B, 10(6), 2000, pp. 435-442

Abstract

Tumor vasculature expresses a number of molecular markers at much lower levels than those seen in the blood vessels of normal tissues, and in some cases, such markers are undetectable. The presence of these markers relates to angiogenesis; the same markers are shared by all blood vessels undergoingangiogenesis. The endothelial cells, pericytes and smooth muscle cells, and the vascular extracellular matrix in angiogenic vessels can each express such markers. Molecularly, they represent vascular growth factor receptors,cell adhesion, proteins and their receptors. Screening of phage display libraries for peptides that home to tumor vasculature when injected into micehas recently provided a new tool for analyzing the distinguishing featuresof tumor vasculature. Tumor-homing peptides isolated in this manner, as well as an antibody against a form of fibronectin expressed in tumor blood vessels, have been found to serve as targeting devices to concentrate drugs and other therapeutic materials to tumors in in vivo models. Such a targeting strategy can therefore potentially improve the efficacy of drugs and reduce their side effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 13:33:36