Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
An antimicrobial peptide gene found in the male reproductive system of rats
Autore:
Li, P; Chan, HC; He, B; So, SC; Chung, YW; Shang, Q; Zhang, YD; Zhang, YL;
Indirizzi:
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200031 200031, Peoples R China Chinese Univ Hong Kong, Fac Med, Dept Physiol, Epithelial Cell Biol Res Ctr, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China
Titolo Testata:
SCIENCE
fascicolo: 5509, volume: 291, anno: 2001,
pagine: 1783 - 1785
SICI:
0036-8075(20010302)291:5509<1783:AAPGFI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INNATE HOST-DEFENSE; CHLAMYDIA-TRACHOMATIS; ANION SECRETION; MESSENGER-RNA; EPIDIDYMIS; ANTIBIOTICS; EPITHELIA; BETA-DEFENSIN-1; EXPRESSION; CHANNEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Zhang, YL Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China Chinese Acad Sci 320 Yue Yang Rd Shanghai Peoples R China 200031
Citazione:
P. Li et al., "An antimicrobial peptide gene found in the male reproductive system of rats", SCIENCE, 291(5509), 2001, pp. 1783-1785

Abstract

Little is known about the innate defense mechanisms of the male reproductive tract. We cloned a 385-base pair complementary DNA and its genomic DNA named Bin1b that is exclusively expressed in the caput region of the rat epididymis and that is responsible for sperm maturation, storage, and protection. Bin1b exhibits structural characteristics and antimicrobial activity similar to that of cationic antimicrobial peptides, beta -defensins. Bin1b ismaximally expressed when the rats are sexually mature and can be up-regulated by inflammation. Bin1b appears to be a natural epididymis-specific antimicrobial peptide that plays a role in reproductive tract host defense and male fertility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 10:28:44