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Titolo:
Neurological comorbidity in parkinsonism.
Autore:
Bodenmann, P; Ghika, J; van Mele, G; Bogousslavsky, J;
Indirizzi:
CHU Vaudois, Neurol Serv, CH-1011 Lausanne, Switzerland CHU Vaudois Lausanne Switzerland CH-1011 , CH-1011 Lausanne, Switzerland
Titolo Testata:
REVUE NEUROLOGIQUE
fascicolo: 1, volume: 157, anno: 2001,
pagine: 45 - 54
SICI:
0035-3787(200101)157:1<45:NCIP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
FRE
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; NORMAL PRESSURE HYDROCEPHALUS; MACHADO-JOSEPH-DISEASE; ESSENTIAL TREMOR; BRAIN-TUMOR; EPIDEMIOLOGY; DIAGNOSIS; DEMENTIA; ASSOCIATION; ASTROCYTOMA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
113
Recensione:
Indirizzi per estratti:
Indirizzo: Ghika, J CHU Vaudois, Neurol Serv, BH 13, CH-1011 Lausanne, Switzerland CHU Vaudois BH 13 Lausanne Switzerland CH-1011 anne, Switzerland
Citazione:
P. Bodenmann et al., "Neurological comorbidity in parkinsonism.", REV NEUROL, 157(1), 2001, pp. 45-54

Abstract

We studied the neurological comorbidity of parkinsonism in 368 consecutivepatients from the Lausanne Movement Disorders Registry. Only 6 patients had no neurological comorbidity. We found that 23p.100 of our patients had ischemic strokes, especially large vessel strokes, ie three times more than in an age-matched control study performed in a recent survey in our country, which is a new finding in contradiction with previous reports mentioning that Parkinson's disease may be a protective factor against stroke. This finding opens new directions for further studies concerning some shared mechanisms in both diseases associated with age. Predominantly tremulous parkinsonism (46p.100) and progressive supranuclear palsy patients (PSP) (40p.100) had the highest prevalence of cerebrovascular disease of all subgroups of parkinsonism, especially lacunar infarcts, which is in accord with a higher frequency of hypertension in these subgroups according to a recent study of ours. Transient ischemic attacks or hemorrhages were not more frequent than in the general population. We did not find a higher frequency of head trauma except for Parkinson's disease, but a trend for a higher frequency of headache and migraine. Brain tumors were more frequent in Parkinson's disease and hydrocephalus and radiculopathies inparkinsonism in general when compared to age-matched populations from the literature. Polyneuropathies were more frequently observed in familial parkinsonism only, but myopathies and cranial neuropathies were not more frequent in our patients. Epilepsy was significantly less frequent in parkinsonism, especially in Parkinson's disease, infectious diseases of the nervous system were rarely encountered and restless legs syndrome was surprisingly not more frequent than in a normal population. Dementia was associated in 20p.100, but multiple sclerosis is noticeably absent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:00:41