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Titolo:
Intraarterial chemotherapy for brain tumors by using a spatial dose fractionation algorithm and pulsatile delivery
Autore:
Gobin, YP; Cloughesy, TF; Chow, KL; Duckwiler, GR; Sayre, JW; Milanese, K; Vinuela, F;
Indirizzi:
Univ Calif Los Angeles, Med Ctr, Dept Radiol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
RADIOLOGY
fascicolo: 3, volume: 218, anno: 2001,
pagine: 724 - 732
SICI:
0033-8419(200103)218:3<724:ICFBTB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT GLIOMAS; PHASE-II; RADIATION-THERAPY; INTRA-ARTERIAL; BCNU; CISPLATIN; CARBOPLATIN; ADULTS; TRIAL; ESCALATION;
Keywords:
brain neoplasms; brain neoplasms, MR; brain neoplasms, therapeutic radiology; chemotherapy, complications; chemotherapy, regional;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Gobin, YP Univ Calif Los Angeles, Med Ctr, Dept Radiol, B7-146A,10833 Le Conte Ave, Los Angeles, CA 90095 USA Univ Calif Los Angeles B7-146A,10833 LeConte Ave Los Angeles CA USA 90095
Citazione:
Y.P. Gobin et al., "Intraarterial chemotherapy for brain tumors by using a spatial dose fractionation algorithm and pulsatile delivery", RADIOLOGY, 218(3), 2001, pp. 724-732

Abstract

PURPOSE: To evaluate the cause of complications in intraarterial chemotherapy for brain tumors and validate a dosage algorithm based on arterial territory. MATERIALS AND METHODS: Four hundred sixty-two procedures were performed in113 patients. Technique included pulsatile infusion of a chemotherapeutic agent. Dosage was calculated per hemisphere and divided per arterial territory according to a spatial dose fractionation algorithm based on the vascular territories of major cerebral arteries: middle cerebral artery, 60%; anterior cerebral artery, 20%; posterior cerebral artery, 15%; and perforator arteries, 5%. Hospital charts of all patients were retrospectively reviewedfor complications, with specific attention given to the angiograms to determine a cause. Then, subgroup analysis of the chemotherapy protocol with the largest patient population was performed to evaluate predictors of complications. RESULTS: Six (1.3%) complications were asymptomatic; 12 (2.6%), transient neurologic; three (0.6%), permanent minor neurologic; three (0.6%), permanent major neurologic; and 32 (7.0%), seizures. In the subgroup analysis, thehemispheric dose administered according to the algorithm was strongly predictive of seizure and neurologic deficit. CONCLUSION: Neurotoxicity of intraarterial cerebral chemotherapy can be minimized by using pulsatile injection and the described spatial dose fractionation algorithm.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 16:42:03