Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Membranous nephropathy, hydrocarbon exposure and genetic variants of hydrocarbon detoxification
Autore:
Gradden, CW; Pai, P; Hindell, P; ODonoghue, DJ; Mason, H; Bell, GM;
Indirizzi:
Royal Liverpool Hosp, Reg Renal Unit, Liverpool L7 8XP, Merseyside, England Royal Liverpool Hosp Liverpool Merseyside England L7 8XP seyside, England Hlth & Safety Lab, Sheffield, S Yorkshire, England Hlth & Safety Lab Sheffield S Yorkshire England ld, S Yorkshire, England Salford Royal Hosp NHS Trust, Dept Renal Med, Manchester, Lancs, England Salford Royal Hosp NHS Trust Manchester Lancs England er, Lancs, England
Titolo Testata:
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
fascicolo: 2, volume: 94, anno: 2001,
pagine: 79 - 87
SICI:
1460-2725(200102)94:2<79:MNHEAG>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYCLIC AROMATIC-HYDROCARBONS; ARYLAMINE N-ACETYLTRANSFERASE; GLUTATHIONE-S-TRANSFERASE; WORSEN RENAL-FUNCTION; OCCUPATIONAL EXPOSURE; UNTREATED PATIENTS; ORGANIC-SOLVENTS; PRIMARY GLOMERULONEPHRITIS; NATURAL-HISTORY; FUNCTION TESTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Gradden, CW Royal Liverpool Univ Hosp Trust, Renal Unit, 6C Link,Prescot St, LiverpoolL7 8XP, Merseyside, England Royal Liverpool Univ Hosp Trust 6C Link,Prescot St Liverpool Merseyside England L7 8XP
Citazione:
C.W. Gradden et al., "Membranous nephropathy, hydrocarbon exposure and genetic variants of hydrocarbon detoxification", QJM-MON J A, 94(2), 2001, pp. 79-87

Abstract

Modulation of biotransformation by genetic traits may be important in determining environmentally-induced nephrotoxicity. We conducted a case-controlstudy to investigate the role of occupational hydrocarbon exposure, along with polymorphisms of the genes coding for N-acetyltransferase 2 (NAT2) andglutathione S-transferase mu (GST mu), in the development of idiopathic membranous glomerulonephritis (IMGN). Patients (n = 36) with biopsy-proven IMGN were matched with healthy controls for age, gender, and geographical area. Lifetime hydrocarbon exposure was assessed by a validated questionnaire. The polymorphisms of the NAT2 and GST mu genes (GSTM1) were defined by useof a polymerase chain reaction on white-cell DNA from peripheral blood. Exposure to hydrocarbons was significantly greater in patients with IMGN thanin controls (mean+/-SEM hydrocarbon exposure score 11 003 +/- 2955.7 vs. 4352 +/- 1418, p<0.02). NAT2 acetylator status was identical in patients andcontrols with 23 (63.9%) fast and 13 (36.1%) slow acetylators in each group. GST<mu> was present in 15 (41.7%) patients and 16 (44.4%) controls. While occupational exposure to hydrocarbons remains a likely factor in its pathogenesis, further work is required to identify the genetic polymorphisms that modulate the risk of IMGN.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 00:45:26