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Titolo:
Split-skin grafting with lidocaine-prilocaine cream: A meta-analysis of efficacy and safety in geriatric versus nongeriatric patients
Autore:
Wahlgren, CF; Lillieborg, S;
Indirizzi:
Karolinska Hosp & Inst, Dept Dermatol & Venereol, Stockholm, Sweden Karolinska Hosp & Inst Stockholm Sweden l & Venereol, Stockholm, Sweden AstraZeneca R&D, Dept Clin R&D, Sodertalje, Sweden AstraZeneca R&D Sodertalje Sweden &D, Dept Clin R&D, Sodertalje, Sweden
Titolo Testata:
PLASTIC AND RECONSTRUCTIVE SURGERY
fascicolo: 3, volume: 107, anno: 2001,
pagine: 750 - 756
SICI:
0032-1052(200103)107:3<750:SGWLCA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERCUTANEOUS-ABSORPTION; EMLA CREAM; PAIN; SCALES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Wahlgren, CF Karolinska Hosp & Inst, Dept Dermatol & Venereol, Stockholm, Sweden Karolinska Hosp & Inst Stockholm Sweden Stockholm, Sweden
Citazione:
C.F. Wahlgren e S. Lillieborg, "Split-skin grafting with lidocaine-prilocaine cream: A meta-analysis of efficacy and safety in geriatric versus nongeriatric patients", PLAS R SURG, 107(3), 2001, pp. 750-756

Abstract

Although the efficacy and safety of the topical anesthetic EMLA cream (lidocaine-prilocaine) have been studied extensively in children and adults, nopublished studies have focused on geriatric patients (greater than or equal to 65 years of age). The objective of this study was to compare the efficacy and safety of EMLA in geriatric versus nongeriatric adults. A pooled analysis was made from original data of six studies of EMLA cream for split-skin grafting. The studies selected had a sufficient number of geriatric andnongeriatric adults and a uniform, standardized pain stimulus (split-skin grafting), pain rating (visual analogue scale, verbal rating scale) and adverse event recording. A total of 182 geriatric patients (82 aged 65 to 74 years; 100 aged 75 to 96 years) and 221 nongeriatric EMLA-treated patients were evaluated. There was no difference in the efficacy of EMLA between geriatric and nongeriatric adults who underwent similar onset and duration of anesthesia. EMLA cream 1.5 g/10 cm(2) applied for 2 to 5 hours and a similaranesthetic effect in both agr groups. A dose of 3 g/10 cm(2) gave no further benefit. In a geriatric population. EMLA cream provided effective cutaneous anesthesia for the cutting of split-skin grafts to the same extent as did infiltrated lidocaine. Adverse event frequency and severity were similarin geriatric and nongeriatric patients. Transient application site pallor,redness, and edema were the most frequent adverse events. Topical anesthesia with EMLA cream for split-skin grafting is as safe and effective in geriatric as in nongeriatric adults.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:44:40