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Titolo:
From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases
Autore:
Goedert, M; Spillantini, MG; Serpell, LC; Berriman, J; Smith, MJ; Jakes, R; Crowther, RA;
Indirizzi:
MRC, Mol Biol Lab, Cambridge CB2 2QH, England MRC Cambridge England CB2 2QH , Mol Biol Lab, Cambridge CB2 2QH, England Univ Cambridge, Brain Repair Ctr, Cambridge CB2 2PY, England Univ Cambridge Cambridge England CB2 2PY Ctr, Cambridge CB2 2PY, England Univ Cambridge, Dept Neurol, Cambridge CB2 2PY, England Univ Cambridge Cambridge England CB2 2PY rol, Cambridge CB2 2PY, England
Titolo Testata:
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
fascicolo: 1406, volume: 356, anno: 2001,
pagine: 213 - 227
SICI:
0962-8436(20010228)356:1406<213:FGTPTA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAIRED HELICAL FILAMENTS; MICROTUBULE-ASSOCIATED PROTEIN; PROGRESSIVE SUPRANUCLEAR PALSY; MULTIPLE-SYSTEM ATROPHY; GLIAL CYTOPLASMIC INCLUSIONS; AMYLOID PRECURSOR PROTEIN; FAMILIAL ALZHEIMERS-DISEASE; SPLICING REGULATORY ELEMENT; INHERITED DEMENTIA FTDP-17; CROSS-BETA CONFORMATION;
Keywords:
tau protein; Alzheimer's disease; Pick's disease; alpha-synuclein; Lewy body diseases; multiple system atrophy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
161
Recensione:
Indirizzi per estratti:
Indirizzo: Goedert, M MRC, Mol Biol Lab, Hills Rd, Cambridge CB2 2QH, England MRC Hills Rd Cambridge England CB2 2QH bridge CB2 2QH, England
Citazione:
M. Goedert et al., "From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases", PHI T ROY B, 356(1406), 2001, pp. 213-227

Abstract

The most common degenerative diseases of the human brain are characterizedby the presence of abnormal filamentous inclusions in affected nerve cellsand glial cells. These diseases can be grouped into two classes, based on the identity of the major proteinaceous components of the filamentous assemblies. The filaments are made of either the microtubule-associated protein tau or the protein alpha -synuclein. Importantly, the discovery of mutations in the tau gene in familial forms of frontotemporal dementia and of mutation in the alpha -synuclein gene in familial forms of Parkinson's disease has established that dysfunction of tau protein and alpha -synuclein can cause neurodegeneration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:50:25