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Titolo:
Central TRH receptor 1 antisense blocks cold-induced gastric emptying but not brain c-Fos induction
Autore:
Martinez, V; Wang, LX; Tache, Y;
Indirizzi:
Univ Calif Los Angeles, VA Wadsworth Greater Los Angeles Hlth Care Syst, Dept Med, Div Digest Dis,Digest Dis Res Ctr,CURE, Los Angeles, CA 90073 USA Univ Calif Los Angeles Los Angeles CA USA 90073 Los Angeles, CA 90073 USA Univ Calif Los Angeles, Inst Brain Res, Los Angeles, CA 90073 USA Univ Calif Los Angeles Los Angeles CA USA 90073 Los Angeles, CA 90073 USA
Titolo Testata:
PEPTIDES
fascicolo: 1, volume: 22, anno: 2001,
pagine: 81 - 90
SICI:
0196-9781(200101)22:1<81:CTR1AB>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROTROPIN-RELEASING-HORMONE; DORSAL MOTOR NUCLEUS; MESSENGER-RNA; RAT-BRAIN; PITUITARY-CELLS; RAPHE-OBSCURUS; VAGAL COMPLEX; SUBSTANCE-P; BODY-TEMPERATURE; ACID-SECRETION;
Keywords:
TRH; TRH receptors; mRNA antisense; oligodeoxynucleotides; c-Fos immunoreactivity; cold exposure; medulla; paraventricular nucleus of the hypothalamus; nucleus tractus solitarius; dorsal vagal complex; raphe pallidus; gastric emptying;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Tache, Y Univ Calif Los Angeles, VA Wadsworth Greater Los Angeles Hlth Care Syst, Dept Med, Div Digest Dis,Digest Dis Res Ctr,CURE, Bldg 115,Rm 117,11301 Wilshire Blvd, Los Angeles, CA 90073 USA Univ Calif Los Angeles Bldg 115,Rm 117,11301 Wilshire Blvd Los Angeles CA USA 90073
Citazione:
V. Martinez et al., "Central TRH receptor 1 antisense blocks cold-induced gastric emptying but not brain c-Fos induction", PEPTIDES, 22(1), 2001, pp. 81-90

Abstract

We studied whether TRH receptor I (TRH-R1) antisense oligodeoxynucleotidesinjected intracisternally, impaired acute cold-induced c-Fos expression inthe brain and vagally mediated stimulation of gastric emptying in conscious rats. Cold exposure (4-6 degreesC, 90 min) increased gastric emptying andthe number of c-Fos positive cells in the paraventricular nucleus of the hypothalamus, supraoptic nucleus, raphe pallidus, dorsal motor nucleus of the vagus, nucleus of the solitary tract and area postrema compared with ratsat room temperature. TRH-R1 antisense abolished cold-induced stimulation of gastric transit but not c-Fos expression in the brain. TRH-RI mismatch did not alter the gastric response to cold. These data indicate that central activation of TRH-RI mediates cold-induced stimulation of gastric emptying but does not influence the induction of c-Fos expression in the brain. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:44:06