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Titolo:
Arginine vasopressin in the cytoplasm and nuclear fraction of lymphocytes from healthy donors and patients with depression or schizophrenia
Autore:
Ekman, R; Gobom, J; Persson, R; Mecocci, P; Nilsson, CL;
Indirizzi:
Univ Gothenburg, Sahlgrenska Hosp, Inst Clin Neurosci, Neurochem Sect, S-43180 Molndal, Sweden Univ Gothenburg Molndal Sweden S-43180 hem Sect, S-43180 Molndal, Sweden Max Planck Inst Mol Genet, Berlin, Germany Max Planck Inst Mol Genet Berlin Germany nst Mol Genet, Berlin, Germany Perugia Univ Hosp, Inst Gerontol & Geriatr, Perugia, Italy Perugia Univ Hosp Perugia Italy Inst Gerontol & Geriatr, Perugia, Italy Univ Gothenburg, Inst Med Biochem, Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden Inst Med Biochem, Gothenburg, Sweden
Titolo Testata:
PEPTIDES
fascicolo: 1, volume: 22, anno: 2001,
pagine: 67 - 72
SICI:
0196-9781(200101)22:1<67:AVITCA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; CHRONIC INFLAMMATORY STRESS; PITUITARY-ADRENAL AXIS; MASS-SPECTROMETRY; MONONUCLEAR-CELLS; BETA-ENDORPHIN; RAT-BRAIN; PEPTIDE; PROTEINS; IMMUNOREACTIVITY;
Keywords:
arginine vasopressin; lymphocytes; radioimmunoassay; high-performance liquid chromatography (HPLC); mass spectrometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Ekman, R Univ Gothenburg, Sahlgrenska Hosp, Inst Clin Neurosci, Neurochem Sect, S-43180 Molndal, Sweden Univ Gothenburg Molndal Sweden S-43180 S-43180 Molndal, Sweden
Citazione:
R. Ekman et al., "Arginine vasopressin in the cytoplasm and nuclear fraction of lymphocytes from healthy donors and patients with depression or schizophrenia", PEPTIDES, 22(1), 2001, pp. 67-72

Abstract

We investigated whether cytoplasmic or nuclear extracts of human peripheral blood lymphocytes contain AVP in samples from healthy controls and patients diagnosed as depressed or schizophrenic. Both the cytoplasmic and nuclear extracts contained AVP as determined by radioimmunoassay. AVP and other peptides were detected in the purified samples by matrix-assisted laser desorption/ionization time of flight mass spectrometry. it is the first time that AVP has been characterized in human lymphocytes of patients with depression or schizophrenia. This finding demonstrates the presence of another important component within the potential I regulatory loop between immune and neuro-endocrine tissues. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:51:33