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Titolo:
Microstructural brain development after perinatal cerebral white matter injury assessed by diffusion tensor magnetic resonance imaging
Autore:
Huppi, PS; Murphy, B; Maier, SE; Zientara, GP; Inder, TE; Barnes, PD; Kikinis, R; Jolesz, FA; Volpe, JJ;
Indirizzi:
Harvard Univ, Sch Med, Childrens Hosp, Dept Radiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Hosp, Dept Radiol, Boston, MA 02115 USA Harvard Univ, Sch Med, Div Newborn Med, Boston, MA USA Harvard Univ Boston MA USA niv, Sch Med, Div Newborn Med, Boston, MA USA Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Radiol, Boston, MA USA Harvard Univ Boston MA USA am & Womens Hosp, Dept Radiol, Boston, MA USA Harvard Univ, Sch Med, Brigham & Womens Hosp, MRI Div, Boston, MA USA Harvard Univ Boston MA USA righam & Womens Hosp, MRI Div, Boston, MA USA Harvard Univ, Sch Med, Childrens Hosp, Dept Neurol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Hosp, Dept Neurol, Boston, MA 02115 USA
Titolo Testata:
PEDIATRICS
fascicolo: 3, volume: 107, anno: 2001,
pagine: 455 - 460
SICI:
0031-4005(200103)107:3<455:MBDAPC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREMATURE-INFANT; IN-VIVO; CHILDREN; MRI; NEWBORNS;
Keywords:
diffusion tensor magnetic resonance imaging; brain development; premature infant; white matter injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Volpe, JJ Harvard Univ, Sch Med, Childrens Hosp, Dept Radiol, Fegan 1103,300 Longwood Ave, Boston, MA 02115 USA Harvard Univ Fegan 1103,300 Longwood Ave Boston MA USA 02115 USA
Citazione:
P.S. Huppi et al., "Microstructural brain development after perinatal cerebral white matter injury assessed by diffusion tensor magnetic resonance imaging", PEDIATRICS, 107(3), 2001, pp. 455-460

Abstract

Objective. Brain injury in premature infants is characterized predominantly by perinatally acquired lesions in the cerebral white matter (WM). The impact of such injury on the subsequent development of cerebral WM is not clear. This study uses diffusion tensor magnetic resonance imaging (MRI) to evaluate the effects of cerebral WM injury on subsequent microstructural brain development in different WM areas of the brain. Methods. Twenty premature infants (gestational age: 29.1 +/- 1.9 weeks) were studied by conventional MRI within the first 3 weeks of life and again at term, with the addition at the latter time of diffusion tensor MRI. Ten of the preterm infants had cerebral WM injury identified by the early MRI and were matched with 10 premature infants of similar gestational age and neonatal course but with normal neonatal MRI scans. Diffusion tensor MRI at term was acquired in coronal and axial planes and used to determine the apparent diffusion coefficient, a measure of overall restriction to water diffusion, and the relative anisotropy (RA), a measure of preferred directionality of diffusion, in central WM, anterior frontal WM, occipital WM, temporal WM, and the posterior limb of the internal capsule. Diffusion vector maps were generated from the diffusion tensor analysis to define the microstructural architecture of the cerebral WM regions. Results. At term, the diffusion tensor MRI revealed no difference in apparent diffusion coefficient among preterm infants with or without perinatal WM lesions. By contrast, RA, the measure of preferred directionality of diffusion and thereby dependent on development of axonal fibers and oligodendroglia, was 25% lower in central WM, the principal site of the original WM injury. However, RA was unaffected in relatively uninjured WM areas, such as temporal, anterior frontal, and occipital regions. Notably, RA values in the internal capsule, which contains fibers that descend from the injured cerebral WM, were 20% lower in the infants with WM injury versus those without. Diffusion vector maps showed striking alterations in the size, orientation, and organization of fiber tracts in central WM and in those descending to the internal capsule. Conclusions. Perinatal cerebral WM injury seems to have major deleterious effects on subsequent development of fiber tracts both in the cerebral WM and more distally. The ultimate impact of brain injury in the newborn shouldbe considered as a function not only of tissue destruction, but also of impaired subsequent brain development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 16:53:25