Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pharmacologic induction of fetal hemoglobin synthesis: Cellular and molecular mechanisms
Autore:
Yang, YM; Pace, B;
Indirizzi:
Univ S Alabama, Coll Med, Dept Pediat, Mobile, AL 36604 USA Univ S Alabama Mobile AL USA 36604 Med, Dept Pediat, Mobile, AL 36604 USA Univ S Alabama, Coll Med, Ctr Comprehens Sickle Cell, Mobile, AL 36604 USAUniv S Alabama Mobile AL USA 36604 hens Sickle Cell, Mobile, AL 36604 USA
Titolo Testata:
PEDIATRIC PATHOLOGY & MOLECULAR MEDICINE
fascicolo: 1, volume: 20, anno: 2001,
pagine: 87 - 106
SICI:
1522-7952(200101)20:1<87:PIOFHS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS-CONTROL REGION; GAMMA-GLOBIN GENE; STAGE SELECTOR ELEMENT; HUMAN ERYTHROID-CELLS; KRUPPEL-LIKE FACTOR; SODIUM-BUTYRATE; F PRODUCTION; HB-F; RISK-FACTORS; HEREDITARY PERSISTENCE;
Keywords:
fetal hemoglobin; hemoglobinopathy; induction; pharmacologic; gamma globin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
125
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, YM Univ S Alabama, Coll Med, Dept Pediat, 1504 Springhill Ave 5230, Mobile, AL 36604 USA Univ S Alabama 1504 Springhill Ave 5230 Mobile AL USA 36604 4 USA
Citazione:
Y.M. Yang e B. Pace, "Pharmacologic induction of fetal hemoglobin synthesis: Cellular and molecular mechanisms", PEDIAT PATH, 20(1), 2001, pp. 87-106

Abstract

The switch from embryonic to fetal then to adult hemoglobin synthesis is aunique phenomenon The during early human development. Fetal hemoglobin (HbF) is known to interfere with polymerization of Hb S in erythrocytes. Several pharmacologic agents such as 5-azacytidine, myleran, hydroxyurea, erthropoietin, and butyrates enhance fetal hemoglobin production and have been used in hemoglobinopathy patients to ameliorate severe pain episodes and reduce severe anemia. Among these, hydroxyurea is the agent of choice because of its safety and ease of administration. One of the primary cellular mechanisms involved in pharmacologic induction of Hb F synthesis is rapid regeneration of erythroid precursors following the cytoreduction phase of certainpharmacologic agents. Molecular mechanisms involving changes in chromatin structure and/or transcription factor binding have been demonstrated for gamma gene induction by butyrate. Identifying the proteins involved in gamma gene activation by various compounds may offer a new strategy for gene therapy to cure hemoglobinopathy disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:37:05