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Titolo:
Hemostatic alterations in sickle cell disease: Relationships to disease pathophysiology
Autore:
Stuart, MJ; Setty, BNY;
Indirizzi:
Thomas Jefferson Univ, Jefferson Med Coll, Dept Pediat, Marian Anderson Comprehens Sickle Cell Anemaia Ca, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA
Titolo Testata:
PEDIATRIC PATHOLOGY & MOLECULAR MEDICINE
fascicolo: 1, volume: 20, anno: 2001,
pagine: 27 - 46
SICI:
1522-7952(200101)20:1<27:HAISCD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMBRANE-PHOSPHOLIPID ASYMMETRY; RED-BLOOD-CELLS; BETA-THALASSEMIA MAJOR; PROTEIN-S DEFICIENCY; ERYTHROCYTE PHOSPHATIDYLSERINE EXPOSURE; TISSUE PLASMINOGEN-ACTIVATOR; VASO-OCCLUSIVE CRISIS; TUMOR-NECROSIS-FACTOR; ANTIPHOSPHOLIPID ANTIBODIES; STEADY-STATE;
Keywords:
anticoagulants; coagulation hemostasis; platelets; sickle cell disease;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
140
Recensione:
Indirizzi per estratti:
Indirizzo: Stuart, MJ Thomas Jefferson Univ, Jefferson Med Coll, Dept Pediat, Marian Anderson Comprehens Sickle Cell Anemaia Ca, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 , PA 19107 USA
Citazione:
M.J. Stuart e B.N.Y. Setty, "Hemostatic alterations in sickle cell disease: Relationships to disease pathophysiology", PEDIAT PATH, 20(1), 2001, pp. 27-46

Abstract

The protean manifestations of sickle cell disease ( SCD), especially, microvessel involvement in the The vaso-occlusive process, is classically ascribed to the phenomena of erythrocyte sickling and enhanced red cell-endothelial adherence. Pertubations in various hemostatic systems occurs in SCD, both in steady state and during vaso-occlusion, with the intravascular generation of thrombin. The etiology(s) of thrombin generation in SCD will be described. Whether the activation of the cellular and plasmatic phases of hemostasis is causative or occurs as a result of vascular injury will be discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:02:31