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Titolo:
Correlation of intact sensibility and neuropathic pain-related behaviors in eight inbred and outbred rat strains and selection lines
Autore:
Shir, Y; Zeltser, R; Vatine, JJ; Carmi, G; Belfer, I; Zangen, A; Overstreet, D; Raber, P; Seltzer, Z;
Indirizzi:
Hebrew Univ Jerusalem, Dept Physiol, Fac Med, IL-91122 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91122 -91122 Jerusalem, Israel Hebrew Univ Jerusalem, Inst Life Sci, Dept Cell & Anim Biol, IL-91122 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91122 -91122 Jerusalem, Israel Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA Univ N CarolinaChapel Hill NC USA 27599 chiat, Chapel Hill, NC 27599 USA Bar Ilan Univ, Inst Life Sci, Ramat Gan, Israel Bar Ilan Univ Ramat Gan Israel n Univ, Inst Life Sci, Ramat Gan, Israel Hebrew Univ Jerusalem, Fac Med Dent, Physiol Branch, Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel hysiol Branch, Jerusalem, Israel Hadassah Univ Hosp, Dept Phys Med & Rehabil, IL-91120 Jerusalem, Israel Hadassah Univ Hosp Jerusalem Israel IL-91120 IL-91120 Jerusalem, Israel Hadassah Univ Hosp, Dept Oral & Maxillofacial Surg, IL-91120 Jerusalem, Israel Hadassah Univ Hosp Jerusalem Israel IL-91120 IL-91120 Jerusalem, Israel Hadassah Univ Hosp, Dept Anesthesiol, IL-91120 Jerusalem, Israel Hadassah Univ Hosp Jerusalem Israel IL-91120 IL-91120 Jerusalem, Israel Hadassah Univ Hosp, Pain Relief Unit, IL-91120 Jerusalem, Israel Hadassah Univ Hosp Jerusalem Israel IL-91120 IL-91120 Jerusalem, Israel
Titolo Testata:
PAIN
fascicolo: 1-2, volume: 90, anno: 2001,
pagine: 75 - 82
SICI:
0304-3959(20010201)90:1-2<75:COISAN>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCIATIC-NERVE INJURY; EXPERIMENTAL-MODEL; AUTOTOMY BEHAVIOR; HERITABILITY; SENSITIVITY; DISORDERS; MOUSE; HYPERALGESIA; NOCICEPTION; ALLODYNIA;
Keywords:
neuropathic pain; partial nerve injury; total denervation; autotomy; allodynia; hyperalgesia; touch sensitivity; noxious heat sensitivity; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Seltzer, Z Hebrew Univ Jerusalem, Dept Physiol, Fac Med, POB 11720, IL-91122 Jerusalem, Israel Hebrew Univ Jerusalem POB 11720 Jerusalem Israel IL-91122 rael
Citazione:
Y. Shir et al., "Correlation of intact sensibility and neuropathic pain-related behaviors in eight inbred and outbred rat strains and selection lines", PAIN, 90(1-2), 2001, pp. 75-82

Abstract

In some rat strains, total hindpaw denervation triggers autotomy, a behavior of self mutilation presumably related to neuropathic pain. Partial sciatic ligation (PSL) in rats produces tactile allodynia and heat hyperalgesia but not autotomy. Our aims in this study were to examine: (1) whether sensibility of intact rats to noxious and non-noxious stimuli is strain-dependent; (2) whether sensibility of intact rats could predict levels of autotomy,or of allodynia and hyperalgesia in the PSL model; and (3) whether autotomy levels are correlated with levels of allodynia or hyperalgesia. Here we report that in two inbred rat strains (Lewis and Fisher 344), two outbred rat strains (Sabra and Sprague-Dawley) and four selection lines of rats (Genetically Epilepsy-Prone Rats, High Autotomy, Low Autotomy and Flinders Sensitive Line), tactile sensitivity and response duration to noxious heat of intact animals were strain-dependent. Levels of autotomy following hindpaw denervation and of allodynia and hyperalgesia in the PSL model were also strain-dependent. Thus, these traits are determined in part by genetic factors. Sensory sensibility of intact rats was not correlated with levels of autotomy following total denervation, or allodynia and hyperalgesia following partial denervation. We suggest that preoperative sensibility of intact rats is not a predictor of levels of neuropathic disorders following nerve injury. Likewise, no correlation was found between autotomy, allodynia and hyperalgesia, suggesting that neuropathic pain behaviors triggered by nerve injury of different etiologies are mediated by differing mechanisms. (C) 2001 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.

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Documento generato il 30/11/20 alle ore 03:35:43