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Titolo:
GABAergic modulation of descending inhibitory systems from the rostral ventromedial medulla (RVM). Dose-response analysis of nociception and neurological deficits
Autore:
Gilbert, AK; Franklin, KBJ;
Indirizzi:
McGill Univ, Dept Psychol, Montreal, PQ H3A 1B1, Canada McGill Univ Montreal PQ Canada H3A 1B1 chol, Montreal, PQ H3A 1B1, Canada
Titolo Testata:
PAIN
fascicolo: 1-2, volume: 90, anno: 2001,
pagine: 25 - 36
SICI:
0304-3959(20010201)90:1-2<25:GMODIS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS RAPHE MAGNUS; DORSAL HORN NEURONS; MORPHINE-INDUCED ANALGESIA; ANESTHETIZED RAT; FORMALIN TEST; REVERSIBLE INACTIVATION; DORSOLATERAL FUNICULUS; PHYSIOLOGICALLY INTACT; PERIAQUEDUCTAL GRAY; RETICULAR-FORMATION;
Keywords:
descending inhibitory controls; muscimol; bicuculline; formalin test; GABA; pain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Franklin, KBJ McGill Univ, Dept Psychol, 1205 Dr Penfield Ave, Montreal, PQ H3A 1B1, Canada McGill Univ 1205 Dr Penfield Ave Montreal PQ Canada H3A 1B1
Citazione:
A.K. Gilbert e K.B.J. Franklin, "GABAergic modulation of descending inhibitory systems from the rostral ventromedial medulla (RVM). Dose-response analysis of nociception and neurological deficits", PAIN, 90(1-2), 2001, pp. 25-36

Abstract

We have examined the effects of muscimol and bicuculline microinjected in the rostral ventromedial medulla (RVM) on motor function and on nociceptionin three pain tests. In Exp. I microinjection of muscimol (6.25-400 ng in 1 mul) in the RVM dose-dependently decreased pain threshold of rats and theED50 for muscimol was the same in both the hot plate and tail immersion pain tests. In the hot plate test, but not in the tail immersion test, paw withdrawal latencies increased again with high doses of muscimol (75-400 ng). High doses also produced catalepsy. Exp. 2 examined the effects of muscimol (50 ng) and bicuculline (50 ng) over a range of formalin concentrations (0.25-4%) in the formalin test. Muscimol increased responsiveness to formalin and reduced the slope of the formalin dose-response relation. Bicucullinedecreased responses to formalin and reduced the slope of the formalin dose-response relation. It is suggested that RVM cells with inhibitory projections to the dorsal horn are not subject to strong GABAergic influence under mild noxious stimulation. RVM cells are thus active, and spinal dorsal hornrelay neurons are inhibited. On the other hand, intense noxious peripheralstimulation may stimulate the release of GABA onto RVM cells, which in turn shuts off descending inhibitory fibers to allow transmission of nociceptor input through the dorsal hem. (C) 2001 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:46:00