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Titolo:
Gemcitabine as single-agent therapy in the management of advanced breast cancer
Autore:
Seidman, AD;
Indirizzi:
Mem Sloan Kettering Canc Ctr, Dept Med, Div Solid Tumor Oncol, Breast CancMed Serv, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA
Titolo Testata:
ONCOLOGY-NEW YORK
fascicolo: 2, volume: 15, anno: 2001, supplemento:, 3
pagine: 11 - 14
SICI:
0890-9091(200102)15:2<11:GASTIT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASE-II TRIAL; PROSPECTIVE RANDOMIZED TRIAL; COMBINATION CHEMOTHERAPY; FIRST-LINE; PACLITAXEL; INFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Seidman, AD Mem Sloan Kettering Canc Ctr, Dept Med, Div Solid Tumor Oncol,Breast CancMed Serv, 1275 York Ave, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr 1275 York Ave New York NY USA 10021
Citazione:
A.D. Seidman, "Gemcitabine as single-agent therapy in the management of advanced breast cancer", ONCOLOGY-NY, 15(2), 2001, pp. 11-14

Abstract

Many active cytotoxic agents exist for breast cancer therapy, and numerouscombination chemotherapy regimens are derived from them. Creating these combinations is sometimes empirically motivated by nonoverlapping toxicities or the expectation of non-cross resistance. Yet, there is usually no absolute division of these aspects among cytotoxic agents, and the median survival for patients with metastatic breast cancer has not been dramatically prolonged by this approach. When the outcome of treatment is palliation rather than cure, it becomes paramount to optimize the dynamic equilibrium betweenchemotherapy-induced side effects and the benefits attributable to relief of cancer-related symptoms. To this end, several recent clinical trials have evaluated the novel nucleoside analog gemcitabine (Gemzar) as single-agent therapy for advanced breast cancer. This article reviews these trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:13:11