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Titolo:
Age-related changes of glutathione content, glucose transport and metabolism, and mitochondrial electron transfer function in mouse brain
Autore:
Sasaki, T; Senda, M; Kim, S; Kojima, S; Kubodera, A;
Indirizzi:
Tokyo Metropolitan Inst Gerontol, Positron Med Ctr, Itabashi Ku, Tokyo 730022, Japan Tokyo Metropolitan Inst Gerontol Tokyo Japan 730022 Tokyo 730022, Japan Sci Univ Tokyo, Biosci Res Inst, Chiba 2788510, Japan Sci Univ Tokyo Chiba Japan 2788510 Biosci Res Inst, Chiba 2788510, Japan Univ Tokyo, Dept Pharmaceut Sci, Shinjuku Ku, Tokyo 1620826, Japan Univ Tokyo Tokyo Japan 1620826 ut Sci, Shinjuku Ku, Tokyo 1620826, Japan
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 1, volume: 28, anno: 2001,
pagine: 25 - 31
SICI:
0969-8051(200101)28:1<25:ACOGCG>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; SENESCENCE-ACCELERATED MOUSE; GAS-TISSUE AUTORADIOGRAPHY; ACETYL-L-CARNITINE; OXYGEN-CONSUMPTION; OXIDATIVE STRESS; RAT; SLICES; TECHNETIUM-99M-MESO-HMPAO;
Keywords:
technetium-99m meso-hexamethyl propyleneamine oxime; [1-C-14]2-deoxy-D-glucose; [O-15]oxygen; visualization; brain; aging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Sasaki, T Tokyo Metropolitan Inst Gerontol, Positron Med Ctr, Itabashi Ku,1-1 Naka Cho, Tokyo 730022, Japan Tokyo Metropolitan Inst Gerontol 1-1 Naka Cho Tokyo Japan 730022
Citazione:
T. Sasaki et al., "Age-related changes of glutathione content, glucose transport and metabolism, and mitochondrial electron transfer function in mouse brain", NUCL MED BI, 28(1), 2001, pp. 25-31

Abstract

To evaluate the oxidative stress-related parameters and to determine theirorder of appearance in the brain aging process, radionuclide experiments were carried out on male DBF1 mice at 3, 12, 24 and 30 months of age. The content of nonprotein sulfhydryl compounds, mainly glutathione, was estimatedwith technetium-99m meso-hexamethyl propyleneamine oxime ([Tc-99m]meso-HMPAO) tissue sampling. Glucose transport and metabolism was examined with [1-C-14]2-deoxy-D-glucose (2-DG) tissue sampling. Mitochondrial electron transport function was estimated with [O-15]O-2 gas-tissue ARG. [Tc-99m]Meso-HMPAO uptake in brain expressed as standardized uptake value (SUV), (radioactivity in brain tissue/tissue weight)/(total administered radioactivity/body weight), reached maximum at 12 months of age and decreased at 24 and 30 months of age in every region examined. The pattern of 2-DG, expressed as SUV,showed a tendency to increase rather than decrease with aging. [O-15]O-2 fixation in brain slices remained constant until 24 months, while it decreased significantly at 30 months of age. The results suggested the possibilityof using imaging techniques in vivo for longitudinal evaluation of the aging process and indicated reduction of nonprotein sulfhydryl compounds including GSH at the early stages of aging may also accelerate the dysfunction of mitochondrial electron transport and neurodegeneration. (C) 2001 ElsevierScience Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:37:26