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Titolo:
Effects of lead on gene expression
Autore:
Bouton, CMLS; Pevsner, J;
Indirizzi:
Kennedy Krieger Inst, Dept Neurol, Baltimore, MD 21205 USA Kennedy KriegerInst Baltimore MD USA 21205 urol, Baltimore, MD 21205 USA Johns Hopkins Sch Med, Dept Neurosci, Baltimore, MD USA Johns Hopkins Sch Med Baltimore MD USA Dept Neurosci, Baltimore, MD USA
Titolo Testata:
NEUROTOXICOLOGY
fascicolo: 6, volume: 21, anno: 2000,
pagine: 1045 - 1055
SICI:
0161-813X(200012)21:6<1045:EOLOGE>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; CENTRAL-NERVOUS-SYSTEM; FIBRILLARY ACIDIC PROTEIN; DEVELOPING RAT-BRAIN; AP-1 DNA-BINDING; MESSENGER-RNA; INORGANIC LEAD; PC12 CELLS; ORNITHINE DECARBOXYLASE; CYTOPLASMIC CALCIUM;
Keywords:
metal; calcium; zinc; transcription; microarray;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Pevsner, J Kennedy Krieger Inst, Dept Neurol, 707 N Broadway, Baltimore, MD 21205 USA Kennedy Krieger Inst 707 N Broadway Baltimore MD USA 21205 USA
Citazione:
C.M.L.S. Bouton e J. Pevsner, "Effects of lead on gene expression", NEUROTOXICO, 21(6), 2000, pp. 1045-1055

Abstract

Lead poisoning is a worldwide, environmental health-hazard that affects children and adults. In this review we discuss the effects of lead on gene expression due to both general and specific mechanisms. In particular we focus on the ability of lead to substitute for biologically essential metals such as calcium and zinc in metal-binding domains of cytoplasmic enzymes, nuclear transcription factors and other proteins. The binding of lead to theseproteins causes an alteration of their activity resulting in aberrant expression of their own genes and in some cases their target genes. Finally, wediscuss the impact of microarray technology on the study of the genome-wide effects of lead and other toxicants on gene expression. (C) 2000 Inter Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 18:43:20